Results 11 to 20 of about 297 (139)

Cell-free DNA methylome and fragmentome analysis for relapse monitoring of Ewing sarcoma [PDF]

EMBO Molecular Medicine
Liquid biopsies and cell-free DNA (cfDNA) offer minimally invasive methods for the diagnosis and monitoring of Ewing Sarcoma (EwS). EwS have a low tumour mutational burden and their detection with plasma cfDNA is challenging.
Sophie A Richardson, Aram Safrastyan, Mina Karimpour, Gayatri Gulati, Patrick J B Harker, Alan Redfern, Simon P Pearce, Vsevolod J Makeev, Bernadette Brennan, Alexander T J Lee, Alexandra Clipson, Steven M Hill, Caroline Dive, Dominic G Rothwell, Martin G McCabe, Florent Mouliere   +15 more
exaly   +4 more sources

Real‐time analysis of the cancer genome and fragmentome from plasma and urine cell‐free DNA using nanopore sequencing [PDF]

EMBO Molecular Medicine, 2023
Cell‐free DNA (cfDNA) can be isolated and sequenced from blood and/or urine of cancer patients. Conventional short‐read sequencing lacks deployability and speed and can be biased for short cfDNA fragments.
Florent Mouliere, Birgit Wever, Idris Bahçe   +2 more
exaly   +4 more sources

Longitudinal cell-free DNA methylome and fragmentome profiles in health uncover signatures of cell type and demographic origin [PDF]

Genome Medicine
Background Cell-free DNA (cfDNA) is a powerful analyte for liquid biopsy applications. However, the composition and fragmentation of cfDNA in health remains incompletely characterized. Understanding this baseline variation is key to advancing cfDNA-based
Huiwen Che, Koenraad Devriendt, Bernard Thienpont   +2 more
exaly   +4 more sources

Early detection and subtyping of gastric cancer: A cell-free DNA fragmentome-based liquid biopsy method [PDF]

IScience
Summary: Cell-free DNA (cfDNA) in plasma provides attractive opportunities for early cancer diagnosis. This study aimed to establish gastric cancer (GC) artificial intelligence algorithms (GC-AIAs) based on cfDNA fragmentome for GC’s early detection and ...
Yongyi Chen, Haiqi Liao, Yuzhi Liu, Liulin Luo, Jiangang Jin, Dingding Hou, Wenjia Liu, Hanqing Zhang, Beilong He, Miao Luo, Wei Liu, Ziao Lin, Songxiao Xu   +12 more
exaly   +4 more sources

Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection [PDF]

Cancer Discovery
Lung cancer screening via annual low-dose computed tomography (LDCT) has poor adoption. We conducted a prospective case-control study among 958 individuals eligible for lung cancer screening to develop a blood-based lung cancer detection test that when ...
Peter Bach, Joseph Catallini, Kwok Kin Wong   +2 more
exaly   +7 more sources

A method of comprehensive sequencing analysis of the small RNA fragmentome (RiboMarker) [PDF]

Rna
Circulating cell-free nucleic acids (cfDNA and cfRNA) found in blood and other biofluids are promising biomarkers for cancer. However, current methods exploiting tumor-derived cfDNA (ctDNA) are not sensitive enough in detecting minimal residual disease and early stages of cancer when it is more treatable.
Aidan C Manning, Sérgio Barberán-Soler, Sergei A Kazakov   +2 more
exaly   +4 more sources

Diagnostics of lung cancer by fragmentated blood circulating cell-free DNA based on machine learning methods [PDF]

Frontiers in Medicine
IntroductionMinimally invasive diagnostics based on liquid biopsy makes it possible early detection of lung cancer (LC). The blood plasma circulating cell-free DNA (cfDNA) fragments reflect the genome and chromatin status and are considered as integral ...
Ivan O. Meshkov, Alexander P. Koturgin, Pavel V. Ershov, Liubov A. Safonova, Julia A. Remizova, Valentina V. Maksyutina, Ekaterina D. Maralova, Vasilisa A. Astafieva, Alexey A. Ivashechkin, Boris D. Ignatiev, Antonida V. Makhotenko, Ekaterina A. Snigir, Valentin V. Makarov, Vladimir S. Yudin, Anton A. Keskinov, Sergey M. Yudin, Anna S. Makarova, Veronika I. Skvortsova   +17 more
doaj   +2 more sources

Multimodal analysis of cell-free DNA whole-methylome sequencing for cancer detection and localization

Nature Communications, 2023
Multimodal epigenetic characterization of cell-free DNA (cfDNA) could improve the performance of blood-based early cancer detection. However, integrative profiling of cfDNA methylome and fragmentome has been technologically challenging. Here, we adapt an
Fenglong Bie, Zhijie Wang, Yulong Li, Wei Guo, Yuanyuan Hong, Tiancheng Han, Fang Lv, Shunli Yang, Suxing Li, Xi Li, Peiyao Nie, Shun Xu, Ruochuan Zang, Moyan Zhang, Peng Song, Feiyue Feng, Jianchun Duan, Guangyu Bai, Yuan Li, Qilin Huai, Bolun Zhou, Yu S. Huang, Weizhi Chen, Fengwei Tan, Shugeng Gao   +24 more
doaj   +2 more sources

Liquid biopsy for early detection of hepatocellular carcinoma [PDF]

Frontiers in Medicine, 2023
Hepatocellular carcinoma (HCC) is a highly prevalent and lethal cancer globally. Over 90% of HCC cases arise in the context of liver cirrhosis, and the severity of the underlying liver disease or advanced tumor stage at diagnosis significantly limits ...
Ioana Manea, Ioana Manea, Ioana Manea, Razvan Iacob, Razvan Iacob, Razvan Iacob, Speranta Iacob, Speranta Iacob, Speranta Iacob, Razvan Cerban, Razvan Cerban, Razvan Cerban, Simona Dima, Simona Dima, Simona Dima, Gabriel Oniscu, Irinel Popescu, Irinel Popescu, Liliana Gheorghe, Liliana Gheorghe, Liliana Gheorghe   +20 more
doaj   +2 more sources

Identification of ᴅ-amino acid-containing peptides in human serum. [PDF]

PLoS ONE, 2017
Biologically uncommon d-aspartate (d-Asp) residues have been shown to accumulate in proteins associated with age-related human disorders, such as cataract and Alzheimer disease.
Seongmin Ha, Ingu Kim, Takumi Takata, Tadatoshi Kinouchi, Masaharu Isoyama, Minoru Suzuki, Noriko Fujii   +6 more
doaj   +2 more sources