Results 61 to 70 of about 297 (139)

Plasma Cell‐Free DNA Concentration and Fragmentomes Predict Neoadjuvant Chemotherapy Response in Cervical Cancer Patients

Advanced Science, Volume 11, Issue 43, November 20, 2024.
Cervical cancer patients with varying responses to neoadjuvant chemotherapy (NACT) exhibit unique patterns of variation in cell‐free DNA (cfDNA) levels and fragmentomic characteristics. The cfDNA emerges as a promising biomarker for predicting tumor response to NACT in cervical cancer, offering a novel approach for monitoring treatment response to ...
Ting Peng, Haiqiang Zhang, Lingguo Li, Canhui Cao, Miaochun Xu, Xiaojie Liu, Shitong Lin, Ping Wu, Tian Chu, Binghan Liu, Yashi Xu, Yan Zhang, Yeqin Wang, Jinjin Yu, Wencheng Ding, Xin Jin, Peng Wu   +16 more
wiley   +1 more source

Circulating tumor DNA methylation detection as biomarker and its application in tumor liquid biopsy: advances and challenges

MedComm, Volume 5, Issue 11, November 2024.
The origin of ctDNA in the bloodstream is derived from CTC, exosomes secreted by tumor cells, apoptotic tumor cells and necrotic tumor cells (A). ctDNA methylation status plays an important role in the occurrence and development of cancer and is a biomarker for tumor liquid biopsy.
Lingyu Li, Yingli Sun
wiley   +1 more source

Circulating Cell-free DNA Fragmentomics Detection and Beyond

aging and disease
Circulating cell-free DNA (cfDNA) comprises DNA fragments released into bodily fluids via apoptosis, necrosis, or phagocytosis. cfDNA encapsulates both fragmentomics (structural) and non-fragmentomics (sequence/epigenetic) information from source cells, thereby representing a promising biomarker.
Tianliang, Liu, Zhicheng, Li, Shifu, Chen, Jiasheng, Zhong   +3 more
openaire   +2 more sources

Advances in early detection of non‐small cell lung cancer: A comprehensive review

Cancer Medicine, Volume 13, Issue 18, September 2024.
Abstract Background Lung cancer has the highest mortality rate among malignancies globally. In addition, due to the growing number of smokers there is considerable concern over its growth. Early detection is an essential step towards reducing complications in this regard and helps to ensure the most effective treatment, reduce health care costs, and ...
Nour Kenaan, George Hanna, Moustafa Sardini, Mhd Omar Iyoun, Khedr Layka, Zein Alabdin Hannouneh, Zuheir Alshehabi   +6 more
wiley   +1 more source

Cell-free DNA fragmentome analysis informs pregnancy outcome in patients with immune-mediated disease

Pregnancy complications contribute substantially to maternal and fetal morbidity and mortality. If complications are suspected early in pregnancy, individuals could be triaged to escalate care and ideally reduce adverse outcomes.
Bernard Thienpont, Ilse Parijs, Kate E. Stanley, Kris Van Den Bogaert, Wilfried Gyselaers, Lore Lannoo, Tatjana Jatsenko, Erika Souche, Koenraad Devriendt, Joris R. Vermeesch, Leen Vancoillie, Ivo Salden, Kristel Van Calsteren   +12 more
core   +1 more source

Cell-free DNA fragmentomics for preeclampsia risk assessment

Nature Communications
Abstract Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that could lead to serious maternal and fetal complications, yet early identification of women at risk remains challenging because reliable biomarkers are limited.
Wenqiu Xu, Songchang Chen, Jia Li, Si Zhou, Yanning Yin, Zhixu Qiu, Jianguo Zhang, Cong Liu, Qiang Zhao, Gefei Xiao, Yan Zhou, Zhiguang Zhao, Xiao Zhang, Wenzhi Yang, Yunfang Wang, Huiqin Li, Zhen Yang, Suihua Feng, Qun Zhang, Weiping Chen, Huahua Li, Xiaohong Ruan, Hua Li, Sufen Zhang, Liqing Hu, Jie Qin, Wuyan Huang, Zhongzhe Li, Xianling Cao, Xuanyou Zhou, Naixin Xu, Dongxia Hou, Hong Dong, Jie Wang, Yaxian Liu, Quanfu Zhang, Xiaohua Wang, Lijian Zhao, Hefeng Huang, Chenming Xu   +39 more
openaire   +1 more source

Cell-Free DNA Fragmentomics: The New “Omics” on the Block [PDF]

Clinical Chemistry, 2020
Rossa W K Chiu, Ellen Heitzer, Y M Dennis Lo, Florent Mouliere, Dana W Y Tsui   +4 more
openaire   +1 more source

Analysis of cfDNA fragmentomics metrics and commercial targeted sequencing panels

Nature Communications
Abstract Fragmentomics based analysis of cell-free DNA (cfDNA) has recently emerged as a method to infer epigenetic and transcriptional data. Many of these reports analyze whole genome sequencing (WGS) which is not readily available clinically. Targeted exon panels are used for clinical cfDNA variant calling.
Kyle T. Helzer, Marina N. Sharifi, Jamie M. Sperger, Matthew R. Chrostek, Matthew L. Bootsma, Shannon R. Reese, Amy Taylor, Katie R. Kaufmann, Hannah Krause, Jennifer Schehr, Nan Sethakorn, David Kosoff, Christos E. Kyriakopoulos, Michael Bassetti, Grace Blitzer, John Floberg, Martin Sjöström, Andrew J. Armstrong, Himisha Beltran, Rana R. McKay, Felix Y. Feng, Ruth O’Regan, Kari B. Wisinski, Hamid Emamekhoo, Alex W. Wyatt, Joshua M. Lang, Shuang G. Zhao   +26 more
openaire   +3 more sources

Mechanistic Modeling of cfDNA Fragmentome Dynamics Predicts Progression to Immunotherapy

BackgroundPlasma cell-free DNA (cfDNA) shows promise as predictive cancer biomarker, but mechanisms governing cfDNA production/fragmentation/elimination dynamics, and their relationships with tumor burden and disease progression, remain poorly understood.
Boutonnet, Audrey, Salas, Sebastien, Nguyen Phuong, Linh, Tomasini, Pascale, Greillier, Laurent, Garcia, Jean-Charles, Ginot, Frédéric, Deville, Jean-Laurent, Fina, Frédéric, Benzekry, Sébastien   +9 more
core   +3 more sources

Leveraging cfDNA fragmentomic features for the early detection of colorectal cancer

Frontiers in Immunology
Background Early detection of colorectal cancer (CRC) is crucial for improving patient outcomes. Cell-free DNA (cfDNA) analysis has emerged as a promising non-invasive approach for cancer detection. This study aims to develop a machine learning algorithm leveraging cfDNA fragmentomic features to accurately ...
Shan, Lina, Xu, Dengyong, Chen, Jie, Liu, Wenjia, Lin, Ji, Bao, Juhang, Huang, Jianfei, Zhang, Hanqing, Zhao, Hanchen, Xue, Wei, Lin, Ziao, Bai, Bingjun   +11 more
openaire   +2 more sources