Results 121 to 130 of about 58,045 (301)

Infectious surgical complications in older adults after emergency abdominal surgery

Revista Cubana de Medicina Militar, 2022
Introduction: Currently, the increase in the aging population associated with the development of anesthesiology, surgery and intensive care has generated an increase in the number of older adults with acute abdomen requiring urgent surgical treatment.
Zenén Rodríguez Fernández, Raúl Mario Calás Balbuena, Gilberto Carlos Falcón Vilariño, Lázaro Ibrahim Romero García, Luís Roberto Piña Prieto   +4 more
doaj  

Mineralized Cryogel/Hydrogel Constructs to Recapitulate Early Breast Cancer Bone Metastasis In Vitro

Advanced Science, EarlyView.
A new biphasic in vitro cryogel/hydrogel model of early breast cancer bone metastasis provides precise control over microenvironmental cues and microscopic access to the spatiotemporal cancer cell distribution. Deposited bone‐like mineral is observed to strongly impede the effects of biomolecular signals, as evidenced by both colonization profiles and ...
Jana Sievers‐Liebschner, Petra B. Welzel, Maximilian Fusenig, Linda Sturm, Dagmar Pette, Wolfgang Wagermaier, Claudia Fischbach, Peter Fratzl, Carsten Werner   +8 more
wiley   +1 more source

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

Advanced Science, EarlyView.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin, Supawadee Jariyasakulroj, Yang Shu, Jingyi Chen, Qing Chang, Pao‐Fen Ko, Yuyueyang Qiu, Feixiang Chen, David Ahn, Zhen Zhao, Jian‐Fu Chen   +10 more
wiley   +1 more source

Microglial Membranes Wrapped Ultrasmall Medium‐Entropy Ru Single‐Atom Nanozyme: Enhanced Catalysis for Accelerating Inflammation/Redox Microenvironment Regulation in Intracerebral Hemorrhage

Advanced Science, EarlyView.
PtRhIr/Ru SAN@M nanozymes cross the blood–brain barrier and selectively accumulate in hemorrhagic brain regions. By mimicking multiple enzyme activities, they attenuate oxidative stress, modulate microglial polarization toward an anti‐inflammatory phenotype, inhibit ferroptosis, and promote neuronal repair.
Jiebo Li, Penghui Wei, Yuanbo Pan, Hongjia Zheng, Jiajun Hu, Qianxi Chen, Zhongyuan Shen, Yongrui Hu, Jiajun Wu, Fuxin Lin, Fuxiang Chen, Chenyu Ding, Wenhua Fang, Yuanxiang Lin, Dezhi Kang, Yuxiang Gu, Yang Zhu, Dengliang Wang   +17 more
wiley   +1 more source

Effects of intervention by trained care managers on advance care planning engagement among long-term care service users in Japan: a pre- and post-pilot comparative study across multiple institutions

Palliative Care and Social Practice
Background: A majority of Japanese care managers lack medical qualifications, feel uncomfortable discussing future medical choices and believe that it is not their responsibility.
Shozo Okochi, Kyoko Oshiro, Noriyasu Takeuchi, Mariko Miyamichi, Tomoe Nakamura, Terumi Matsushima, Masako Okada, Yoshimi Kudo, Takehiro Ishiyama, Tomoyasu Kinoshita, Hideki Kojima, Mitsunori Nishikawa   +11 more
doaj   +1 more source

A Universal Metal–Flavonoid Coating Strategy: Engineering Biomaterials for Diabetic Bone Regeneration

Advanced Science, EarlyView.
Construction of metal–flavonoid functionalized coatings on conventional bone repair materials. A one‐pot method is used to directly construct multifunctional metal–flavonoid coatings on the surface of traditional bone repair materials by selecting metal ions with osteogenic/angiogenic properties and flavonoids with reactive oxygen species scavenging ...
Chen Yang, Chenle Dong, Lefeng Su, Zhiqiang Liu, Lingyi Hu, Qishu Jin, Hao Chen, Chunlong Zhang, Yihao Wu, Jiang Chang, Zhaowenbin Zhang, Jiandong Yuan   +11 more
wiley   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Advancing Direct Alcohol Fuel Cells: Innovations in Composite‐Based Electrocatalysts and Polymer Support Materials for Enhanced Efficiency

Advanced Energy and Sustainability Research, EarlyView.
This graphical abstract emphasizes the working principle and the various essential factors of the direct methanol fuel cell (DMFCs). Additionally, various parameters, such as the nanoparticle's size and shape, the nature of the electrolyte, the type of support materials, and their fabrication process, also play essential roles in the functioning of the
Kirti Mishra, Samarjeet Singh Siwal, Phil Hart, Vijay Kumar Thakur   +3 more
wiley   +1 more source

Cities and Satellites: Spatial Effects and Unobserved Heterogeneity in the Modeling of Urban Growth [PDF]

The confluence of factors driving urban growth is highly complex, resulting from a combination of ecological and social determinants that co-evolve over time and space.
Colin Vance, Rich Iovanna
core  

Prognostic Utility of the Preoperative Cachexia Index in Patients Undergoing Emergency Laparotomy

Annals of Gastroenterological Surgery, EarlyView.
The preoperative cachexia index, incorporating muscle mass, nutritional status, and inflammation, predicts in‐hospital and one‐year mortality in patients undergoing emergency laparotomy. This simple index may aid in risk stratification and perioperative decision‐making in high‐risk surgical patients. ABSTRACT Aim Emergency laparotomy is associated with
Naoko Fukushima, Takahiro Masuda, Kazuto Tsuboi, Masami Yuda, Keita Takahashi, Fumiaki Yano, Ken Eto   +6 more
wiley   +1 more source