Results 21 to 30 of about 22,375 (217)

Validation of the clinical frailty score (CFS) in French language

BMC Geriatrics, 2019
Background Very old critical ill patients are a rapid expanding group. To better understand the magnitude of the challenges involved in intensive care practice for an ageing population and discuss a rational allocation of resources, healthcare ...
Paul Abraham, Delphine S. Courvoisier, Cedric Annweiler, Cliff Lenoir, Thomas Millien, Francoise Dalmaz, Hans Flaatten, Rui Moreno, Steffen Christensen, Dylan W. de Lange, Bertrand Guidet, Karim Bendjelid, Bernhard Walder, Bernardo Bollen Pinto   +13 more
doaj   +1 more source

Frailty in Cardiac Surgery—Assessment Tools, Impact on Outcomes, and Optimisation Strategies: A Narrative Review

Journal of Cardiovascular Development and Disease
Background: Advancements in surgical care have made it possible to offer cardiac surgery to an older and frailer patient cohort. Frailty has been recognised as a prognostic indicator that impacts post-operative recovery and patient outcomes.
Ashwini Chandiramani, Jason M. Ali
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Frailty recommendations and guidelines. An evaluation of implementability and critical appraisal of clinical applicability by the ISPRM Frailty Focus Group

The Journal of the International Society of Physical and Rehabilitation Medicine
Objective:. Aging is associated with an increased burden of multimorbidity and disease-related functional loss and disability, widely impacting patients and health care systems.
Eleftheria Antoniadou, MD, PhD, Emanuele Maria Giusti, PhD, Paolo Capodaglio, MD, Dersheng HAN, MD, Francesca Gimigliano, MD, Juan Manuel Guzman, MD, Mooyeon OhPARK, MD, Walter Frontera, MD   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Differences of expected intervention effects between participant-led and facilitator-led preventive care services in Japan

Hong Kong Journal of Occupational Therapy, 2021
Objective To examine the effect of different management methods on the effectiveness of care preventive programmes for community-dwelling older adults.
Shan Yun, Risa Takashima, Kazuki Yoshida, Daisuke Sawamura, Takao Inoue, Shinya Sakai   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

ANTENNEBEROEPEN IN DE LOKALE GEMEENSCHAP ALS SLEUTEL VOOR DOORVERWIJZING VAN KWETSBARE OUDEREN NAAR HULPORGANISATIES

Journal of Social Intervention, 2019
SAMENVATTINGZowel in Vlaanderen als in Nederland werd de voorbije jaren sterk geïnvesteerd in preventie en interventieprogramma’s om kwetsbaarheid bij ouderen tegen te gaan. Kwetsbaarheid wordt doorgaans gedetecteerd door gezondheidsprofessionals.
Daan Duppen, An-Sofie Smetcoren, Sylvia Hoens, Karmien Nackaerts, Liesbeth de Donder   +4 more
doaj   +1 more source

Throughput delays: causes, predictors, and outcomes – observational cohort in a Swiss emergency department

Swiss Medical Weekly, 2023
BACKGROUND: Optimal throughput times in emergency departments can be adjudicated by emergency physicians. Emergency physicians can also define causes of delays during work-up, such as waiting for imaging, clinical chemistry, consultations, or exit ...
Isabelle Arnold, Jeannette-Marie Busch, Lukas Terhalle, Christian H. Nickel, Roland Bingisser   +4 more
doaj   +1 more source