Results 31 to 40 of about 25,104 (242)
Nutrition in Older Adults: A Primary Care Perspective on Malnutrition, Sarcopenia, Frailty and Gut Microbiota [PDF]
Eurasian Journal of Family MedicineNutrition is an important component of healthy ageing and the primary care of older adults. This review synthesises clinically relevant evidence on malnutrition, dehydration, sarcopenia, frailty, micronutrient deficiency, and gut microbiota, based on a ...
Remziye Kendirci Katırcı +1 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Frailty and chronic kidney disease : current evidence and continuing uncertainties
, 2018 Frailty, the state of increased vulnerability to physical stressors as a result of progressive and sustained degeneration in multiple physiological systems, is common in those with chronic kidney disease (CKD).
Dhaygude, Ajay +5 more
core +3 more sources
Frailty recommendations and guidelines:an evaluation of the implementability and a critical appraisal of clinical applicability by the ISPRM Frailty Focus Group [PDF]
INTRODUCTION: Aging is associated with an increased burden of multi-morbidity and disease related functional loss and disability, widely impacting patients and health care systems.
null, null +8 more
core +6 more sources
Hong Kong Journal of Occupational Therapy, 2021 Objective To examine the effect of different management methods on the effectiveness of care preventive programmes for community-dwelling older adults.
Shan Yun +5 more
doaj +1 more source
Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source
Journal of Social Intervention, 2019 SAMENVATTINGZowel in Vlaanderen als in Nederland werd de voorbije jaren sterk geïnvesteerd in preventie en interventieprogramma’s om kwetsbaarheid bij ouderen tegen te gaan. Kwetsbaarheid wordt doorgaans gedetecteerd door gezondheidsprofessionals.
Daan Duppen +4 more
doaj +1 more source