Results 41 to 50 of about 25,104 (242)

Throughput delays: causes, predictors, and outcomes – observational cohort in a Swiss emergency department

Swiss Medical Weekly, 2023
BACKGROUND: Optimal throughput times in emergency departments can be adjudicated by emergency physicians. Emergency physicians can also define causes of delays during work-up, such as waiting for imaging, clinical chemistry, consultations, or exit ...
Isabelle Arnold, Jeannette-Marie Busch, Lukas Terhalle, Christian H. Nickel, Roland Bingisser   +4 more
doaj   +1 more source

Management of frailty: opportunities, challenges, and future directions

, 2019
Frailty is a complex age-related clinical condition characterised by a decline in physiological capacity across several organ systems, with a resultant increased susceptibility to stressors.
Woo, Jean, Romero-Ortuno, Roman, Bergman, Howard, Romero-Ortuno, R., Dent, E., Woo, J., Walston, Jeremy D., Walston, J.D., Martin, F.C., Martin, Finbarr C., Bergman, H., Dent, Elsa   +11 more
core   +1 more source

Incidence of Frailty in Community-Dwelling United States Older Veterans

, 2021
Determine the incidence rates of frailty among community-dwelling older veterans. Population-based retrospective cohort study. Veterans Health Administration Medical Center study included community-dwelling veterans 60 years and older with determinations
Mohammed, Yaqub Nadeem, Aparicio-Ugarriza, Raquel, Nasr, Lubna A, Ruiz, Sergio J, Ruiz, Jorge G, Ganta, Nagapratap, Sikandar, Sehrish, Tang, Fei, Cevallos, Victor   +8 more
core   +1 more source

Individuals With Multijoint Osteoarthritis Demonstrate Larger Longitudinal Declines in Frailty: Data From the Canadian Longitudinal Study on Aging

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to test the hypothesis that multijoint osteoarthritis would modify the relation between time and frailty progression, in which more affected joints would lead to larger declines over six years compared to those without osteoarthritis using data from the Canadian Longitudinal Study on Aging.
Carson Halliwell, Rebecca Moyer, Myles W. O'Brien   +2 more
wiley   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Periphere Cholinesterasen als Prädiktoren der postoperativen Frailty-Verschlechterung [PDF]

, 2021
Hintergrund: Die Zahl der operativen Eingriffe an älteren Menschen steigt kontinuierlich. Im perioperativen Kontext sind ältere Personen Stressfaktoren ausgesetzt, die sie aufgrund ihrer reduzierten körperlichen Reserven bisweilen nur eingeschränkt ...
Dörfler, Juliane
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Prevention Admission into Nursing homes (PAN): study protocol for an explorative, prospective longitudinal pilot study

BMC Geriatrics, 2022
Background In Switzerland, there is a lack of adequate rehabilitation services, and effective coordination, that take into account the multifactorial health risks of older people.
Andrea L. Koppitz, Susanne Suter-Riederer, Gabriela Bieri-Brünig, Heike Geschwinder, Anita Keller Senn, Frank Spichiger, Thomas Volken   +6 more
doaj   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source