Results 61 to 70 of about 22,515 (245)

NutriLive: An Integrated Nutritional Approach as a Sustainable Tool to Prevent Malnutrition in Older People and Promote Active and Healthy Ageing—The EIP-AHA Nutrition Action Group

Advances in Public Health, 2016
The present document describes a nutritional approach that is nested in the European Innovation Partnership for Active and Healthy Aging (EIP-AHA) and aims to provide the first common European program translating an integrated approach to nutritional ...
Maddalena Illario, Angela Serena Maione, Maria Rosaria Rusciano, Edwig Goossens, Amelia Rauter, Nidia Braz, Harriet Jager-Wittenaar, Carolina Di Somma, Catherine Crola, Maria Soprano, Laura Vuolo, Pietro Campiglia, Guido Iaccarino, Helen Griffiths, Tobias Hartman, Donatella Tramontano, Annamaria Colao, Regina Roller-Wirnsberger   +17 more
doaj   +1 more source

Reorienting frailty in clinical practice, public health, and policy: the Lancet Commission on Frailty

WHO's policy framework for healthy ageing from the World Report on Ageing and Health recognises frailty as the foremost geriatric syndrome in older adults and a key determinant of functional ability.1 Frailty poses a major public health challenge, with a
Clegg, Andrew, Roller-Wirnsberger, R., Dent, E., Roller-Wirnsberger, Regina, Hoogendijk, Emiel O, Vetrano, Davide Liborio, Clegg, A., Hoogendijk, E.O., Dent, Elsa, Vetrano, D.L.   +9 more
core   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

2156

Journal of Clinical and Translational Science, 2017
OBJECTIVES/SPECIFIC AIMS: This study is part of a parent grant evaluating antidiabetic medications and risk for heart failure in an observational cohort of Veterans with type 2 diabetes (T2DM).
Caroline Presley, Marie Griffin, Jea Young Min, Robert Greevy, Christianne Roumie   +4 more
doaj   +1 more source

CD44‐Targeting Hydroxyapatite Nanoparticles (HAP) Induce Mitochondrial Dysfunction‐Driven PANoptosis and Immunogenic Cell Death (ICD) via Ca Overload in Colorectal Cancer

Advanced Science, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao, Yuxuan Yang, Haosen Qiu, Jia Yang, Hao Liang, Zhaojun Jiang, Xiao Tong, Yongying Li, Qunfeng Huang, Jiaming Wu, Tian Lin, Jiang Yu, Min Liang   +12 more
wiley   +1 more source

Reasons for seeking emergency care for geriatric patients with paroxysmal atrial fibrillation, and the effectiveness of pre-hospital treatment

Российский журнал гериатрической медицины
BACKGROUND. One of the most common age-related conditions is atrial fibrillation (AF). The development of AF in geriatric patients leads to the inevitable prescription of additional medications: anticoagulants and means to control rhythm or frequency ...
A. D. Veber, D. S. Maksimova, S. V. Eshmakov   +2 more
doaj   +1 more source

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

The use of a frailty index to predict adverse postoperative outcomes of older surgical patients (Reply)

, 2018
Thank you for your comments on our paper titled Perioperative assessment of older surgical patients using a frailty index–feasibility and association with adverse postoperative outcomes1 .
Lin, H-S, Sivalingam, P, McBride, RL, Nelson, MJ, Scott, IA, Peel, NM, Morong, JJ, Vardesh, DL, Hubbard, RE   +8 more
core  

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Frailty, Sarcopenia and Nutrition

Recently, the terms frailty and sarcopenia have been used frequently. Frailty, which occurs due to age-related physiological changes in multiple systems, is accepted as one of the geriatric syndromes.
Okur,İ.N., Hızlı,Ş., Yesil,B.O.
core   +1 more source