Results 61 to 70 of about 5,010,058 (349)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

La Turquie : instrument de politisation, objet de politisation

European Journal of Turkish Studies, 2015
This paper analyses the politicization process in France of Turkey’s EU bid. In 2002 the President of the Convention on the future of Europe, V. Giscard d’Estaing, was one of the first leaders to take a strong political stand against Turkey’s EU bid. The
Claire Visier
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

COGNITIVE SEMANTICS OF NOUNS IN DENUMERATIVE WORD FORMATION (BASED ON UKRAINIAN LANGUAGE) [PDF]

Alfred Nobel University Journal of Philology
Revival of interest in the linguistic-cognitive interpretation of the deep level of language, as a means of facilitating the computerization of the semantic continuum of derived words, is driven by the schemati- zation of both implicit and explicit ...
Olha V. Kostryba
doaj   +1 more source

Single-Frame, Multiple-Frame and Framing Motifs in Genes [PDF]

Life, 2019
We study the distribution of new classes of motifs in genes, a research field that has not been investigated to date. A single-frame motif SF has no trinucleotide in reading frame (frame 0) that occurs in a shifted frame (frame 1 or 2), e.g., the dicodon AAACAA is S F as the trinucleotides AAA and CAA do not occur in a shifted frame.
openaire   +4 more sources

Do Spinors Frame-Drag?

, 2010
We investigate the effect of the intrinsic spin of a fundamental spinor field on the surrounding spacetime geometry. We show that despite the lack of a rotating stress-energy source (and despite claims to the contrary) the intrinsic spin of a spin-half ...
Andrew Randono, B. Mashhoon, B. Mashhoon, I. Ciufolini, J. D. Jackson, V. de Sabbata, W. Arkuszewski   +6 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Fusion frames and g-frames

Journal of Mathematical Analysis and Applications, 2008
The authors study generalized, i.e., \(g\)-frames in a Hilbert space \(U\), that is, sequences \((\Lambda_i)_{i\in I}\) of linear operators \(\Lambda_i:U\to V_i\) such that \[ A\| f\| ^2 \leq \sum_{i\in I} \| \Lambda_i f\| ^2 \leq B \| f\| ^2, \] for some positive constants \(A\) and \(B\).
Khosravi, Amir, Musazadeh, Kamran
openaire   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

ارزیابی ریسک حریق در آزمایشگاه های دانشگاه علوم پزشکی با استفاده از روش FRAME [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 2020
زمینه و هدف:آزمایشگاه‌های تحقیقاتی دانشگاه‌ها نقش مهمی در ارتقاء آموزش عالی به عهده دارند. عواملی همچون مواد شیمیایی آتشگیر ،تنوع فعالیتهای آزمایشگاهی، موضوع ایمنی حریق را به یکی از چالش های اصلی ایمنی در آزمایشگاه تبدیل کرده است. پیشگیری از حریق جهت حفظ
مصطفی میرزایی علی‌آبادی, فاطمه رستمی, محسن مهدی‌نیا, اعظم کرمی مسافر, جلیل درخشان, مریم فیض عارفی   +5 more
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