Results 101 to 110 of about 59,619 (217)

Small Molecule‐Based Conditional Gene Regulation: Advances and Applications

Chemistry–Methods, Volume 6, Issue 4, April 2026.
The precise, temporal, and reversible control of gene expression using small molecule ligands is crucial for understanding complex cellular functions and is rapidly advancing the field of synthetic biology. Small molecule‐mediated conditional gene regulation has widespread applications, including bio‐manufacturing, cellular reprogramming, gene therapy,
Mohd Afaque Ansari, Riddhima Sharma, Priyanka Swami, Ambadas B. Rode   +3 more
wiley   +1 more source

Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania. [PDF]

, 2017
Knowledge of viral diversity is expanding greatly, but many lineages remain underexplored. We surveyed RNA viruses in 52 cultured monoxenous relatives of the human parasite <i>Leishmania</i> ( <i>Crithidia</i> and <i> ...
Akopyants, N.S., Beverley, S.M., Butenko, A., d'Avila-Levy, C.M., Dobson, D.E., Fasel, N., Frolov, A.O., Grybchuk, D., Konovalovas, A., Kostygov, A.Y., Kulich, P., Lukeš, J., Lye, L.F., Moravcová, J., Plevka, P., Rogozin, I.B., Serva, S., Votýpka, J., Yurchenko, V., Zangger, H.   +19 more
core   +1 more source

Web Service for Finding Ribosomal Frameshifts [PDF]

, 2006
Recent advances in biomedical research have generated a huge amount of data and software to deal with the data. Many biomedical systems use heterogeneous data structures and incompatible software components, so integration of software components into a system can be hindered by incompatibilities between the components of the system. This paper presents
Yanga Byun, Sanghoon Moon, Kyungsook Han
openaire   +1 more source

Transcription Factors GATA1/2 in Hematological Disorders

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Background GATA1 and GATA2 are zinc‐finger transcription factors essential for normal hematopoiesis. As genetic testing becomes more widely integrated into clinical practice, GATA1/2‐related disorders are increasingly recognized, making it important for clinicians to understand their diagnosis and management.
Matthew Karr, Neil Palmisiano, Xiaoyi Chen   +2 more
wiley   +1 more source

Discovery of frameshifting in Alphavirus 6K resolves a 20-year enigma

Virology Journal, 2008
Background The genus Alphavirus includes several potentially lethal human viruses. Additionally, species such as Sindbis virus and Semliki Forest virus are important vectors for gene therapy, vaccination and cancer research, and important models for ...
Fleeton Marina N, Chung Betty YW, Firth Andrew E, Atkins John F   +3 more
doaj   +1 more source

High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome Profiling. [PDF]

, 2016
Members of the family Coronaviridae have the largest genomes of all RNA viruses, typically in the region of 30 kilobases. Several coronaviruses, such as Severe acute respiratory syndrome-related coronavirus (SARS-CoV) and Middle East respiratory syndrome-
Brierley, Ian, Chung, Betty Y-W, Firth, Andrew E, Irigoyen, Nerea, Jones, Joshua D, Siddell, Stuart G   +5 more
core   +3 more sources

Thermodynamic stability of recoding RNA pseudoknots and ribosomal frameshifting [PDF]

, 2001
Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the ...
Cannon, Brian Ray
core  

Ribosomes slide on lysine-encoding homopolymeric A stretches. [PDF]

, 2015
Protein output from synonymous codons is thought to be equivalent if appropriate tRNAs are sufficiently abundant. Here we show that mRNAs encoding iterated lysine codons, AAA or AAG, differentially impact protein synthesis: insertion of iterated AAA ...
Brunelle, Julie L, Djuranovic, Sergej, Green, Rachel, Koutmou, Kristin S, Radhakrishnan, Aditya, Schuller, Anthony P   +5 more
core   +3 more sources

Reliable Inference of Phylogenomic Relationship via Assembly‐Based Strategy Accommodating Raw Reads and Proteins

Molecular Ecology Resources, Volume 26, Issue 3, April 2026.
ABSTRACT Phylogenomics is a transformative approach in systematics, conservation biology, and biomedical research, enabling the inference of evolutionary relationships by leveraging hundreds to thousands of genes from genomic or transcriptomic data. However, acquiring high‐quality genomes and transcriptomes necessitates samples with intact DNA and RNA,
Yunlong Li, Xu Liu, Chong Chen, Jian‐Wen Qiu, Kevin M. Kocot, Jin Sun   +5 more
wiley   +1 more source

The mitochondrial genome of the hexactinellid sponge : Evidence for programmed translational frameshifting [PDF]

, 2008
Background Mitochondrial genomes (mtDNA) of numerous sponges have been sequenced as part of an ongoing effort to resolve the class-level phylogeny of the Porifera, as well as to place the various lower metazoan groups on the animal-kingdom tree.
Leys Sally P, Moreno Maria A, Sperling Erik A, Rosengarten Rafael D, Dellaporta Stephen L   +4 more
core   +1 more source