Results 61 to 70 of about 568,347 (304)
International Journal of Communication, 2020 This article examines the effects of trust versus doubt news frames during the 2018 denuclearization summit between the United States and North Korea in June 2018, an issue that is characterized by negative media coverage about North Korea and its leader
Chang Sup Park, Barbara K. Kaye
doaj +2 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Tempus Fugit: Time Pressure in Risky Decisions [PDF]
, 2011 We study the effects of time pressure on risky decisions for pure gain prospects, pure loss prospects, and mixed prospects involving both gains and losses.
Kocher, Martin G. +2 more
core +2 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Bracketing effects on risk tolerance: Generalizability and underlying mechanisms
Judgment and Decision Making, 2010 Research has shown that risk tolerance increases when multiple decisions and associated outcomes are presented together in a broader “bracket” rather than one at a time.
Ester Moher, Derek J. Koehler
doaj +1 more source
Public Support for Transport Reform: Does it Matter if we ‘Reduce Driving’ or ‘Shift Trips’?
Findings, 2021 Does what the public says they want in terms of transport policy depend on how we ask? In other words, are transportation policy preferences subject to framing effects?
Kelcie Ralph +3 more
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
The framing effect in a monetary gambling task is robust in minimally verbal language switching contexts [PDF]
, 2018 Decision-making biases, in particular the framing effect, can be altered in foreign language settings (foreign language effect) and following switching between languages (the language switching effect on framing). Recently, it has been suggested that the
Heekeren, Hauke R. +2 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Individual sensitivity to framing effects [PDF]
Surveys are sometimes viewed with suspicion when used to provide economic values, since they are sensitive to framing effects. However, the extent to which those effects may vary between individuals has received little attention.
Emmanuel Flachaire, Guillaume Hollard
core