Results 101 to 110 of about 12,487 (338)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Annona muricata (graviola): toxic or therapeutic [PDF]

, 2008
This paper examines annona muricata (graviola): toxic or ...
Gray, A.I., Hollinshead, J., Jones, L., Jones, P.W., Mohanty, S., Thomas, D., Watson, A.A., Watson, D.G.   +7 more
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

SPARC 2019 Fake news & home truths : Salford postgraduate annual research conference book of abstracts [PDF]

, 2019
Welcome to the Book of Abstracts for the 2019 SPARC conference. This year we not only celebrate the work of our PGRs but also our first ever Doctoral School Best Supervisor awards, which makes this year’s conference extra special.
Aarons, Toby, Abduljawad, SAMAH ABDULHADI S, Aboelkheir, Aya, Addis, Maria Chiara, Adeboye, OG, Adeniyi, Ibukun Abimbola, Adesina, Raphael Adeyinka, Ajisope, Tayo Ayanbola, Alanazi, Badriah Alhumaidh, Alghamdi, Wael, Alhajri, Mubarak, Ali, Iftikar, Alrehily, Faisal, Alresheedi, Nadi, Alshamsi, Ibrahim, Apejoye, Adeyanju, Asdullah, Muhammad Ashar, Baghaei, Milad, Barnes, EM, Barton, Lucy Susan, Blezard, Eve, Boahene, TS, Borun, Anna, Broeks, Lonneke, Carvalho, MARIA LUIZA DE ULHOA, Chinta, Sowmya, Clark, Anna, Dailah, HGH, Demonte, Philippa, Demonte, Philippa, Dixon, Tracy, Edwin, Marysa, Garbutt, Marrianne, Gbobaniyi, Andrea, Gbolagun, Vashti Suwa, Gbolagun, Vashti Suwa, Gilanliogullari, Nazemin, Greenhalgh, Stephen, Gunaratne, Pasan, Halilu gidado, ABUBAKAR, Hameed, Wael, Hassan, KABIRU JEGA, Hussain, Aisha, Iheme, MA, Iheme, MA, Iseghohimen, A, Jackson-Ware, Orla, Jones, Matthew Allan, Kassaman, Dinah, Kuharat, Sireetorn, Kulger, Katrin, Lenka, Jessica Lapshak, Macarthy, Ruth, Makarfi, UU, Mattix, Daniel, Mitchell, Louise, Moghaddam, Maryam Farzin, Mohammed, NUHU, Moore, Zoe, Morlando, Sonia, Namuguzi, Mary, Namukwaya, Caroline, Nnadi, Modestus Ikechukwu, Nuttall, John Robert, Nuttall, John Robert, Nwedu, Aaron Beryl, Odero, STEPHEN ODHIAMBO, Osmanu, Muniratu Aliu, Papathanasiou, Stamatia, Prasetyo, ANDHIKA PRIMA, Sadiq, Ibrahim, Safari, Nazila, Saffar, Nehal, Seekles, ML, Skidmore, Sue, Stoddart, Kirsten, Tilde, Aisha Ibrahim, Tomar, Neha, Toth, Fanni, Tran, Phuong Anh, White, Carolyn, Whitehead, Helen Claire, Willcock, MS, Willcock, MS, Wu, Mei Feng, Yadav, Richa, Yalmi, GILBERT, Yaradua, Kabir Hassan, Yoma, Matias, Yusup, Nor Hafizah   +89 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

De Mi Mama [PDF]

, 2019
I come from hard earth and clay walls.I come from early Sunday mornings-the smell of myrrh and frankincense clouding my eyes.I come from the mango trees that did not belong to me,But still scaled up high to escape a life that was not ...
Puente, Adrianna
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source