Results 121 to 130 of about 12,487 (338)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Distribution, ecology, and threats assessment of 11 endemic frankincense tree taxa (Boswellia) in the Socotra Archipelago (Yemen)

Plants, People, Planet
Conserving frankincense trees (Boswellia) is crucial for both ecological and socio‐economic reasons. Surveying these trees in the field and using remote sensing unmanned aerial vehicles in the Socotra Archipelago, we found that Socotran frankincense ...
P. Maděra, P. Vahalík, Salem Hamdiah, K. Hušková, Jiří Sekava, F. Attorre, D. La Montagna, Michele De Sanctis, R. Nétek, Frans Bongers, M. Rivers, Jan Šebesta, Mohammad Amar, Salem Keybani, Mohammad Shanayeghen, Kay Van Damme   +15 more
semanticscholar   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Frankincense preparation promotes formation of inflammation-resolving lipid mediators by manipulating lipoxygenases in human innate immune cells

Frontiers in Pharmacology
Introduction: Frankincense preparations are frequently used as traditional anti-inflammatory remedies in folk medicine with increasing popularity. Boswellic acids (BAs), especially 3-O-acetyl-11-keto-βBA (AKBA), are unique anti-inflammatory principles of
Vivien Nischang, Finja Witt, Friedemann Börner, Mario Gómez, P. M. Jordan, O. Werz   +5 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Psalms for Skeptics (101-150)

, 2014
Sparked by phrases from the book of Psalms, these poems question and occasionally affirm our everyday ideas about life, mortality, the afterlife, God, family, and belief.
Gramm, Kent L.
core  

Utilització de l'extracte vegetal boswellia serrata gum en formulacions cosmètiques [PDF]

, 2008
La cosmètica és un món en constant evolució. És una industria que mou quantitats de diners molt grans i que inverteix molt en investigació i desenvolupament.
Naudí Moreno, Rosa
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Cassane diterpenoids from lonchocarpus laxiflorus [PDF]

, 2008
This article examines cassane diterpenoids from lonchocarpus ...
Gray, A.I., Igoli, J.O., Letzel, M.C., Nwaji, M.N., Onyiriuka, S.O.   +4 more
core  

Modified frankincense resin stabilized gold nanoparticles for enhanced antioxidant and synergetic activity in in-vitro anticancer studies.

International Journal of Biological Macromolecules
For the first time, Frankincense resin (FR) has been carboxymethylated to produce CMFR - AuNPs and the conjugate was utilized for the Doxorubicin drug loading.
Kondaiah Seku, G. Bhagavanth Reddy, Ahmed I. Osman, S. Hussaini, Nadavala Siva Kumar, Mohammed Al-Abri, Babu Pejjai, S. Alreshaidan, A. Al-Fatesh, K. K. Kadimpati   +9 more
semanticscholar   +1 more source