Results 131 to 140 of about 12,487 (338)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Qualitative phytochemical profiling, antioxidant activity, and development of a water-in-oil cream containing combined oil and water infusions of frankincense resin (Boswellia spp.): a preliminary in vitro study

Journal of Pharmacy & Pharmaceutical Sciences
BackgroundFrankincense (gum olibanum, Boswellia spp.) is an oleo-gum resin widely used in traditional medicine and cosmetics owing to the presence of volatile oils and pentacyclic triterpenic acids (boswellic acids) with reported anti-inflammatory and ...
Shamama Javed, Ahmad Salawi, Sivakumar S. Moni, Sivakumar S. Moni, Waquar Ahsan, Gulrana Khuwaja, Md Shamsher Alam, Durgaramani Sivadasan, Aamena Jabeen, Maram Yahya Aziabi, Hind Mohammed Suwaydi, Taif Eassa M. Alajam, Amwaj Yahya Marwai Nammazi, Nourah Mohammed Ahmed Kadumi   +13 more
doaj   +1 more source

A study of the clinical efficacy of frankincense in the acute phase of ischemic stroke [PDF]

, 2015
Background and aims: Ischemic stroke is the most common type of stroke and its most important symptoms are paralysis and movement disorders. Therefore, finding a method for treating this disorder is greatly important.
Azizi, Mahmoud., Jivad, Nahid., Khosravi, Shamsali., Rafieian-Kopaei, Mahmoud., Rezaei-Kheirabadi, Fakhri.   +4 more
core  

Assessment of Lavender, Frankincense and Peppermint Oils Trans-dermal Nano Spray Formulation Effect on Wound Healing Activity in Rat Model

Egyptian Journal of Veterinary Sciences
study is to investigate the Nano spray formulation containing a combination of lavender, frankincense and peppermint oils for burn healing potential using rat-burn induced model.
G. Safwat, Zeinab A. El-Gendy, L. Ramadan, H. Fathy, Omima I. Ezzo, M. Rostom, Fayez Fouda   +6 more
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Comparative characterization of Hojari and Sha'bi frankincense (Boswellia sacra) with implications for food quality and safety

Frontiers in Sustainable Food Systems
IntroductionFrankincense (Boswellia sacra) is a traditional non-timber forest product increasingly incorporated into food and beverage formulations, yet information on the quality attributes and food safety implications of different commercial grades ...
Zahra S. Al-Kharousi, Ann S. Mothershaw, Mohammad Shafiur Rahman   +2 more
doaj   +1 more source

Pharmacological Activities of Boswellia serrata Roxb. - Mini Review [PDF]

, 2009
Boswellia serrata (Salai Guggal) is one of the most ancient and respected herbs in Ayurveda. “Gajabhakshya” a Sanskrit name sometimes used for Boswellia suggests that elephants enjoy this herb as a part of their diet.
Ghule, Balu, Upaganlawar, Aman
core   +1 more source

Frankincense (Boswellia serrata) Extract Effects on Growth and Biofilm Formation of Porphyromonas gingivalis, and Its Intracellular Infection in Human Gingival Epithelial Cells

Current Issues in Molecular Biology
Frankincense is produced by Boswellia trees, which can be found throughout the Middle East and parts of Africa and Asia. Boswellia serrata extract has been shown to have anti-cancer, anti-inflammatory, and antimicrobial effects.
David Vang, A. C. Moreira-Souza, Nicholas T. Zusman, G. Moncada, Harmony Matshik Dakafay, Homer Asadi, David M. Ojcius, C. Almeida-da-Silva   +7 more
semanticscholar   +1 more source