Results 191 to 200 of about 60,935 (313)

Localising enzymes to biomolecular condensates increases their accumulation and benefits engineered metabolic pathway performance in Nicotiana benthamiana

open access: yesPlant Biotechnology Journal, EarlyView.
Summary The establishment of Nicotiana benthamiana as a robust biofactory is complicated by issues such as product toxicity and proteolytic degradation of target proteins/introduced enzymes. Here we investigate whether biomolecular condensates can be used to address these problems. We engineered biomolecular condensates in N.
Anya L. Lindström Battle   +3 more
wiley   +1 more source

Losing control: REF 2029 and the downgrading of academic outputs

open access: yesTransactions of the Institute of British Geographers, EarlyView.
Abstract In June 2023 UKRI (UK Research and Innovation) announced that the contribution of research outputs to the next REF (Research Excellence Framework) exercise will be radically reduced. In addition, the link between individuals and research publications is to be replaced by a more generic emphasis on ‘research culture’. In this commentary I argue
Matthew Gandy
wiley   +1 more source

FRAP-S2: a computer code for the steady state analysis of oxide fuel rods

open access: green, 1977
J.A. Dearien   +4 more
openalex   +2 more sources

Efficient in vivo targeting of the myocardial scar using Moloney murine leukaemia virus complexed with nanoparticles

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The complexation of Moloney murine leukaemia virus (MMLV) with magnetic nanoparticles (MNP) greatly enhanced the transduction of (myo)fibroblasts (FB), when applied in a magnetic field, both in vitro and in vivo in cryoinjured mice.
Timo Mohr   +11 more
wiley   +1 more source

Catecholaminergic polymorphic ventricular tachycardia–linked ryanodine receptor variants exhibit domain‐specific calcium leak and calmodulin affinity properties

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi   +11 more
wiley   +1 more source

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