Results 131 to 140 of about 10,061 (229)

Regional Differences in Soybean Protein and Amino Acid Profiles: A Genetic Exploration Using a Novel GWAS Panel

Legume Science, Volume 7, Issue 4, December 2025.
ABSTRACT Regional differences in soybean seed protein and amino acid content in Canada present significant challenges for crop improvement and the market value of high‐protein livestock feed. This study employed genome‐wide association studies (GWAS) using a novel panel of 206 cultivars to investigate the genetic basis of regional variations.
Siwar Haidar, Simon Lackey, Aga Pajak, Mohamad S. Elian, Vi Nguyen, Jakob Bruggink, Loretta Ross, Fuyou Fu, Jonathan Durkin, Milad Eskandari, Ashkan Golshani, Zenglu Li, Lone Buchwaldt, Yuhai Cui, Anfu Hou, Yong‐Bi Fu, Krzysztof Szczyglowski, Elroy Cober, Frédéric Marsolais, Bahram Samanfar   +19 more
wiley   +1 more source

AAV Gene Therapy Drug Development and Translation of Engineered Ocular and Neurotropic Capsids: A Systematic Review Using Natural Language Processing

Clinical and Translational Science, Volume 18, Issue 12, December 2025.
ABSTRACT Natural AAV serotypes often lack specificity and efficiency, leading to off‐target effects and a low therapeutic index. To overcome these limitations of naturally occurring serotypes, there has been a keen interest in the field to engineer novel capsids to enhance tissue and cell‐specific targeting, resulting in a high number of published ...
Chinaza Agbim, Heng‐Yi Wu, Chloe Kim, Elizabeth Mutter‐Rottmayer, Shraddha Sadekar, Milica Markovic   +5 more
wiley   +1 more source

Mammalian iron-sulfur cluster biogenesis: Recent insights into the roles of frataxin, acyl carrier protein and ATPase-mediated transfer to recipient proteins.

Current Opinion in Chemical Biology, 2020
The recently solved crystal structures of the human cysteine desulfurase NFS1, in complex with the LYR protein ISD11, the acyl carrier protein ACP, and the main scaffold ISCU, have shed light on the molecular interactions that govern initial cluster ...
N. Maio, Anshika Jain, T. Rouault
semanticscholar   +1 more source

Human adipose stem cell-conditioned medium increases survival of Friedreich's Ataxia cells submitted to oxidative stress [PDF]

, 2012
Friedreich's ataxia (FA) is a multisystemic disorder characterized by progressive gait, ataxia, and cardiomyopathy. There are few treatments for this disease; thus, we analyzed in vitro the possible beneficial effect of adult stem cells in FA.
Bueno, Carlos Roberto, Estirado, Alicia, Jones, Jonathan, Martínez, Salvador, Redondo, Carolina   +4 more
core   +2 more sources

Loss of ANK3 Function Causes a Recessive Neurodevelopmental Disorder with Cerebellar Ataxia

Movement Disorders, Volume 40, Issue 11, Page 2531-2537, November 2025.
Abstract Background ANK3 encodes ankyrin‐G, a key scaffolding protein essential for neuronal function. While both monoallelic and biallelic ANK3 variants have been linked to neurodevelopmental disorders (NDDs), existing evidence for their pathogenicity and clinical correlation remains limited and heterogeneous.
Reza Maroofian, Giulia Spoto, Dalila Moualek, Maha S. Zaki, Asthik Biswas, Felice D'Arco, Sajjad Biglari, Pooneh Nikuei, Joseph G. Gleeson, Meriem Tazir, Lamia Ali Pacha, Henry Houlden   +11 more
wiley   +1 more source

Spastic Ataxia Composite (SPAXCOM): A Scale to Evaluate the Progression of Subjects with Spasticity and Ataxia

Movement Disorders, Volume 40, Issue 11, Page 2476-2485, November 2025.
Abstract Background Current clinical scales that track disease progression are more tailored to spasticity or ataxia, with limited sensitivity to change. Objectives The aim was to develop a sensitive and valid scale specifically geared towards optimized sensitivity to change and adapted to patients presenting with both spasticity and ataxia.
Cécile Di Folco, Charlotte Dubec‐Fleury, Andreas Traschütz, Christoph Kessler, Selina Reich, Cynthia Gagnon, Isabelle Lessard, Xavier Rodrigue, Sirio Cocozza, Sara Satolli, Filippo M. Santorelli, Alexandra Durr, Anna Heinzmann, Bart P. van de Warrenburg, Ilse H.J. Willemse, A. Nazli Başak, Atay Vural, Bernard Brais, Stephan Klebe, Rita Horvath, PROSPAX Consortium, May Yung Tiet, Heather Biggs, Emma Harrison, Dagmar Timmann, Nicole Jeschonneck, Paulina Cunha, Hortense Hurmic, Lucie Pierron, Giulia Coarelli, Claire Ewenczyk, Ivana Ricca, Melissa Barghigiani, Nazan Akkaya, Özgür Öztop Çakmak, Rebecca Schüle, Matthis Synofzik, Sophie Tezenas du Montcel   +37 more
wiley   +1 more source

Oxidative stress modulates rearrangement of endoplasmic reticulum-mitochondria contacts and calcium dysregulation in a Friedreich's ataxia model

Redox Biology, 2020
Friedreich ataxia (FRDA) is a neurodegenerative disorder characterized by neuromuscular and neurological manifestations. It is caused by mutations in the FXN gene, which results in loss of the mitochondrial protein frataxin.
Laura R. Rodríguez, Pablo Calap-Quintana, Tamara Lapeña-Luzón, Federico V. Pallardó, Stephan Schneuwly, Juan A. Navarro, Pilar Gonzalez-Cabo   +6 more
doaj   +1 more source

Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells [PDF]

, 2015
The final published version can be found here: http://dx.doi.org/10.1073/pnas ...
Anna Karlsson, Choksi, Deli A, Jayeta Saxena, Joanne Betts, Kiebish, Kim, L. Miguel Martins, Melania Capasso, Nick V. Henriquez, Paolo Salomoni, Pierluigi Nicotera, Sara Galavotti, Schwartzbaum, Sebastian Brandner, Stefano Bartesaghi, Valentina Minieri, Vincenzo De Laurenzi, Vincenzo Graziano   +18 more
core   +1 more source

Flavin adenine dinucleotide rescues the phenotype of frataxin deficiency.

PLoS ONE, 2010
BackgroundFriedreich ataxia is a neurodegenerative disease caused by the lack of frataxin, a mitochondrial protein. We previously demonstrated that frataxin interacts with complex II subunits of the electronic transport chain (ETC) and putative ...
Pilar Gonzalez-Cabo, Sheila Ros, Francesc Palau   +2 more
doaj   +1 more source

Mechanism of activation of the human cysteine desulfurase complex by frataxin

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance In humans, essential iron-sulfur (Fe-S) cluster cofactors are synthesized using an assembly complex that depends on the protein frataxin (FXN).
Shachin Patra, D. Barondeau
semanticscholar   +1 more source