Results 61 to 70 of about 5,673 (157)

A pool of extramitochondrial frataxin that promotes cell survival

, 2006
Frataxin is a mitochondrial protein involved in iron metabolism. Defective expression of frataxin causes Friedreich ataxia (FA), an inherited degenerative syndrome characterized by ataxia, cardiomyopathy, and high incidence of diabetes.
Ventura, N, Condò, I, CONDO', IVANO, MALISAN, FLORENCE, TESTI, ROBERTO, Malisan, F, Tomassini, B, Testi, R   +7 more
core   +1 more source

Oral Presentation

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Detection of frataxin-EGFP fusion protein.

, 2014
Western blot analysis was carried out on protein extracts from liver tissue of FXN-EGFP transgenic mice and C57BL/6 control mice. Identical blots were probed with either anti-human frataxin monoclonal antibody (A) or with anti-GFP polyclonal antibody (B).
David I. Finkelstein (227752), Lingli Li (61106), Timothy P. Holloway (542599), Panos A. Ioannou (214510), Joseph P. Sarsero (214516)   +4 more
core   +1 more source

ePoster

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Cisplatin May Induce Frataxin Expression

Journal of Nippon Medical School, 2003
Cisplatin is a widely used drug in cancer chemotherapy and resistance to cisplatin is a major limitation for its successful application. Intracellular inactivation of cisplatin and detoxification of reactive oxygen species (ROS) by glutathione (a crucial cellular antioxidant) is a mechanism for cisplatin resistance.
openaire   +3 more sources

Functional characterization of Frataxin isoforms and mechanisms of regulation of frataxin expression

, 2019
Esta tesis tiene embargado el acceso al texto completo hasta el 04-01 ...
openaire   +1 more source

Impaired Glur2 palmitoylation in cerebellar Purkinje cells of a Friedreich ataxia mouse model. [PDF]

Exp Neurol
Mercado-Ayón E, Coulman J, Lee JY, Lancaster E, Goga E, Asad M, Witze E, Lynch DR.   +7 more
europepmc   +1 more source

Frataxin deficiency enhances apoptosis in cells differentiating into neuroectoderm.

, 2001
Deficiency of the mitochondrial matrix protein frataxin causes Friedreich ataxia. Frataxin function is believed to be related to mitochondrial iron metabolism and free radical production.
Pandolfo, Massimo, Ohshima, K, Santos, M M   +2 more
core  

Dysregulation of sphingolipid-metabolizing enzymes in Friedreich's ataxia: <i>In vitro</i> and <i>in vivo</i> insights into therapeutic targeting. [PDF]

iScience
Ramchunder Z, Kalef-Ezra E, Suleman S, Edzeamey FJ, Szunyogh S, Gittins O, Castro Mena N, Wade-Martins R, Valle A, Pourzand C, Anjomani Virmouni S.   +10 more
europepmc   +1 more source

Mitochondrial Quality Control in Inherited Mitochondrial Cardiomyopathy: Convergent Pathobiology and a Testable Therapeutic Framework. [PDF]

Int J Mol Sci
Lee CL, Chuang CK, Chang YH, Chiu HC, Tu YR, Lo YT, Wu JY, Huang HY, Lin HY, Lin SP.   +9 more
europepmc   +1 more source