Results 31 to 40 of about 201,538 (315)

An Optimized Approach for Serial Crystallography Using Chips

Crystals, 2023
Serial crystallography is a rapidly developing method for the determination of the structure of biomolecules at room temperature at near-atomic resolution from an ensemble of small crystals. Numerous advances in detectors, data analysis pipelines, sample
Marina Galchenkova, Aida Rahmani Mashhour, Patrick Y. A. Reinke, Sebastian Günther, Jan Meyer, Henry N. Chapman, Oleksandr M. Yefanov   +6 more
doaj   +1 more source

Operational experience with Adaptive Gain Integrating Pixel Detectors at European XFEL

Frontiers in Physics
The European X-ray Free Electron Laser (European XFEL) is a cutting-edge user facility that generates per second up to 27,000 ultra-short, spatially coherent X-ray pulses within an energy range of 0.26 to more than 20 keV.
Jolanta Sztuk-Dambietz, Vratko Rovensky, Alexander Klujev, Torsten Laurus, Ulrich Trunk, Karim Ahmed, Olivier Meyer, Johannes Möller, Andrea Parenti, Natascha Raab, Roman Shayduk, Marcin Sikorski, Gabriele Ansaldi, Ulrike Bösenberg, Lopez M. Luis, Astrid Muenich, Thomas R. Preston, Philipp Schmidt, Stephan Stern, Richard Bean, Anders Madsen, Luca Gelisio, Steffen Hauf, Patrick Gessler, Krzysztof Wrona, Heinz Graafsma, Heinz Graafsma, Monica Turcato   +27 more
doaj   +1 more source

The Quantum Free-Electron Laser [PDF]

, 2018
CERN Yellow Reports: School Proceedings, Vol 1 (2018): Proceedings of the CAS-CERN Accelerator School on Free Electron Lasers and Energy Recovery ...
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Room-temperature X-ray fragment screening with serial crystallography

Nature Communications
Structural insights into protein-ligand interactions are essential for advancing drug development, with macromolecular X-ray crystallography being a cornerstone technique.
Sebastian Günther, Pontus Fischer, Marina Galchenkova, Sven Falke, Patrick Y. A. Reinke, Sreevidya Thekku Veedu, Ana Carolina Rodrigues, Johanna Senst, Daniel Elinjikkal, Lars Gumprecht, Jan Meyer, Henry N. Chapman, Miriam Barthelmess, Alke Meents   +13 more
doaj   +1 more source

Efficient electronic structure calculation for molecular ionization dynamics at high x-ray intensity

Structural Dynamics, 2015
We present the implementation of an electronic-structure approach dedicated to ionization dynamics of molecules interacting with x-ray free-electron laser (XFEL) pulses.
Yajiang Hao, Ludger Inhester, Kota Hanasaki, Sang-Kil Son, Robin Santra   +4 more
doaj   +1 more source

Ultrafast orbital tomography of a pentacene film using time-resolved momentum microscopy at a FEL

Nature Communications, 2022
Ultrafast pulses are useful to investigate the electron dynamics in excited atoms, molecules and other complex systems. Here, the authors measure transient photoelectron momentum maps following the free-electron laser pulse-induced ionization of a ...
Kiana Baumgärtner, Marvin Reuner, Christian Metzger, Dmytro Kutnyakhov, Michael Heber, Federico Pressacco, Chul-Hee Min, Thiago R. F. Peixoto, Mario Reiser, Chan Kim, Wei Lu, Roman Shayduk, Manuel Izquierdo, Günter Brenner, Friedrich Roth, Achim Schöll, Serguei Molodtsov, Wilfried Wurth, Friedrich Reinert, Anders Madsen, Daria Popova-Gorelova, Markus Scholz   +21 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

MHz X-ray photon correlation spectroscopy using an acoustic levitator at the European XFEL

Journal of Synchrotron Radiation
The structural and dynamical properties of soft-matter systems play an important role in crystallization and nucleation theory. Despite their significance, the dynamical properties are still poorly understood because of experimental constraints and the ...
Wonhyuk Jo, Johannes Möller, Jörg Hallmann, James Wrigley, Jan-Etienne Pudell, Ulrike Boesenberg, Felix Brausse, Angel Rodriguez-Fernandez, Alexey Zozulya, Roman Shayduk, Anders Madsen   +10 more
doaj   +1 more source