Results 31 to 40 of about 190,999 (265)

Spectral phase control of interfering chirped pulses for high-energy narrowband terahertz generation

Nature Communications, 2019
Optical generation of terahertz radiation is needed for many applications, but gaining high efficiency is still a challenge. The authors report a method to overcome dispersion effects in interfering chirp pulses used for THz pulse production by tuning ...
Spencer W. Jolly, Nicholas H. Matlis, Frederike Ahr, Vincent Leroux, Timo Eichner, Anne-Laure Calendron, Hideki Ishizuki, Takunori Taira, Franz X. Kärtner, Andreas R. Maier   +9 more
doaj   +1 more source

Towards Realistic Simulations of Macromolecules Irradiated under the Conditions of Coherent Diffraction Imaging with an X-ray Free-Electron Laser

Photonics, 2015
Biological samples are highly radiation sensitive. The rapid progress of their radiation damage prevents accurate structure determination of single macromolecular assemblies in standard diffraction experiments. However, computer simulations of the damage
Beata Ziaja, Zoltan Jurek, Nikita Medvedev, Vikrant Saxena, Sang-Kil Son, Robin Santra   +5 more
doaj   +1 more source

Controlled beams of shock-frozen, isolated, biological and artificial nanoparticles

Structural Dynamics, 2020
X-ray free-electron lasers promise diffractive imaging of single molecules and nanoparticles with atomic spatial resolution. This relies on the averaging of millions of diffraction patterns of identical particles, which should ideally be isolated in the ...
Amit K. Samanta, Muhamed Amin, Armando D. Estillore, Nils Roth, Lena Worbs, Daniel A. Horke, Jochen Küpper   +6 more
doaj   +1 more source

Ultrafast orbital tomography of a pentacene film using time-resolved momentum microscopy at a FEL

Nature Communications, 2022
Ultrafast pulses are useful to investigate the electron dynamics in excited atoms, molecules and other complex systems. Here, the authors measure transient photoelectron momentum maps following the free-electron laser pulse-induced ionization of a ...
Kiana Baumgärtner, Marvin Reuner, Christian Metzger, Dmytro Kutnyakhov, Michael Heber, Federico Pressacco, Chul-Hee Min, Thiago R. F. Peixoto, Mario Reiser, Chan Kim, Wei Lu, Roman Shayduk, Manuel Izquierdo, Günter Brenner, Friedrich Roth, Achim Schöll, Serguei Molodtsov, Wilfried Wurth, Friedrich Reinert, Anders Madsen, Daria Popova-Gorelova, Markus Scholz   +21 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Free electron laser.

The Review of Laser Engineering, 1987
Concepts and historical review of free electron laser are reported. Since the experiment at Stanford University was successful in 1977, great numberof FEL experiments with various accelerators were successfully performed to observe amplification and oscillation of radiations in the wavelength range of 0.5 μm-103μm.
openaire   +2 more sources

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Calculation of x-ray scattering patterns from nanocrystals at high x-ray intensity

Structural Dynamics, 2016
We present a generalized method to describe the x-ray scattering intensity of the Bragg spots in a diffraction pattern from nanocrystals exposed to intense x-ray pulses. Our method involves the subdivision of a crystal into smaller units.
Malik Muhammad Abdullah, Zoltan Jurek, Sang-Kil Son, Robin Santra   +3 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source