Results 41 to 50 of about 201,538 (315)

Spectral phase control of interfering chirped pulses for high-energy narrowband terahertz generation

Nature Communications, 2019
Optical generation of terahertz radiation is needed for many applications, but gaining high efficiency is still a challenge. The authors report a method to overcome dispersion effects in interfering chirp pulses used for THz pulse production by tuning ...
Spencer W. Jolly, Nicholas H. Matlis, Frederike Ahr, Vincent Leroux, Timo Eichner, Anne-Laure Calendron, Hideki Ishizuki, Takunori Taira, Franz X. Kärtner, Andreas R. Maier   +9 more
doaj   +1 more source

Towards Realistic Simulations of Macromolecules Irradiated under the Conditions of Coherent Diffraction Imaging with an X-ray Free-Electron Laser

Photonics, 2015
Biological samples are highly radiation sensitive. The rapid progress of their radiation damage prevents accurate structure determination of single macromolecular assemblies in standard diffraction experiments. However, computer simulations of the damage
Beata Ziaja, Zoltan Jurek, Nikita Medvedev, Vikrant Saxena, Sang-Kil Son, Robin Santra   +5 more
doaj   +1 more source

Free electron laser.

The Review of Laser Engineering, 1987
Concepts and historical review of free electron laser are reported. Since the experiment at Stanford University was successful in 1977, great numberof FEL experiments with various accelerators were successfully performed to observe amplification and oscillation of radiations in the wavelength range of 0.5 μm-103μm.
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Controlled beams of shock-frozen, isolated, biological and artificial nanoparticles

Structural Dynamics, 2020
X-ray free-electron lasers promise diffractive imaging of single molecules and nanoparticles with atomic spatial resolution. This relies on the averaging of millions of diffraction patterns of identical particles, which should ideally be isolated in the ...
Amit K. Samanta, Muhamed Amin, Armando D. Estillore, Nils Roth, Lena Worbs, Daniel A. Horke, Jochen Küpper   +6 more
doaj   +1 more source

The Oxford free electron laser project

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1990
It is proposed to use the Oxford 10 MV Van de Graaff accelerator as an electron beam source for a free electron laser (FEL) operating in the far infra red (FIR). The configuration and layout of the Van de Graaff make it very suitable for conversion, with a potentially high efficiency for electron beam recovery. Using a 2 m long wiggler of 34 mm period,
Allison, W, Brau, C, Brooks, C, Doucas, G, Elgin, J, Gillespie, W, Holmes, A, Jaroszynski, D, Kimmitt, M, Martin, P, Mulvey, J, Pidgeon, C, Poole, M   +12 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Calculation of x-ray scattering patterns from nanocrystals at high x-ray intensity

Structural Dynamics, 2016
We present a generalized method to describe the x-ray scattering intensity of the Bragg spots in a diffraction pattern from nanocrystals exposed to intense x-ray pulses. Our method involves the subdivision of a crystal into smaller units.
Malik Muhammad Abdullah, Zoltan Jurek, Sang-Kil Son, Robin Santra   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source