Results 41 to 50 of about 564,176 (286)

Room-temperature X-ray fragment screening with serial crystallography

Nature Communications
Structural insights into protein-ligand interactions are essential for advancing drug development, with macromolecular X-ray crystallography being a cornerstone technique.
Sebastian Günther, Pontus Fischer, Marina Galchenkova, Sven Falke, Patrick Y. A. Reinke, Sreevidya Thekku Veedu, Ana Carolina Rodrigues, Johanna Senst, Daniel Elinjikkal, Lars Gumprecht, Jan Meyer, Henry N. Chapman, Miriam Barthelmess, Alke Meents   +13 more
doaj   +1 more source

MHz X-ray photon correlation spectroscopy using an acoustic levitator at the European XFEL

Journal of Synchrotron Radiation
The structural and dynamical properties of soft-matter systems play an important role in crystallization and nucleation theory. Despite their significance, the dynamical properties are still poorly understood because of experimental constraints and the ...
Wonhyuk Jo, Johannes Möller, Jörg Hallmann, James Wrigley, Jan-Etienne Pudell, Ulrike Boesenberg, Felix Brausse, Angel Rodriguez-Fernandez, Alexey Zozulya, Roman Shayduk, Anders Madsen   +10 more
doaj   +1 more source

Efficient electronic structure calculation for molecular ionization dynamics at high x-ray intensity

Structural Dynamics, 2015
We present the implementation of an electronic-structure approach dedicated to ionization dynamics of molecules interacting with x-ray free-electron laser (XFEL) pulses.
Yajiang Hao, Ludger Inhester, Kota Hanasaki, Sang-Kil Son, Robin Santra   +4 more
doaj   +1 more source

Towards Realistic Simulations of Macromolecules Irradiated under the Conditions of Coherent Diffraction Imaging with an X-ray Free-Electron Laser

Photonics, 2015
Biological samples are highly radiation sensitive. The rapid progress of their radiation damage prevents accurate structure determination of single macromolecular assemblies in standard diffraction experiments. However, computer simulations of the damage
Beata Ziaja, Zoltan Jurek, Nikita Medvedev, Vikrant Saxena, Sang-Kil Son, Robin Santra   +5 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Spectral phase control of interfering chirped pulses for high-energy narrowband terahertz generation

Nature Communications, 2019
Optical generation of terahertz radiation is needed for many applications, but gaining high efficiency is still a challenge. The authors report a method to overcome dispersion effects in interfering chirp pulses used for THz pulse production by tuning ...
Spencer W. Jolly, Nicholas H. Matlis, Frederike Ahr, Vincent Leroux, Timo Eichner, Anne-Laure Calendron, Hideki Ishizuki, Takunori Taira, Franz X. Kärtner, Andreas R. Maier   +9 more
doaj   +1 more source

Imaging Molecular Structure through Femtosecond Photoelectron Diffraction on Aligned and Oriented Gas-Phase Molecules [PDF]

, 2014
This paper gives an account of our progress towards performing femtosecond time-resolved photoelectron diffraction on gas-phase molecules in a pump-probe setup combining optical lasers and an X-ray Free-Electron Laser.
Adolph, Marcus, Anielski, Denis, Aquila, Andrew, Bari, Sadia, Boll, Rebecca, Bomme, Cedric, Bostedt, Christoph, Bozek, John D., Chapman, Henry N., Christensen, Lauge, Coffee, Ryan, Coppola, Niccola, De, Sankar, Decleva, Piero, Epp, Sascha W., Erk, Benjamin, Filsinger, Frank, Foucar, Lutz, Gorkhover, Tais, Gumprecht, Lars, Hoemke, Andre, Holmegaard, Lotte, Johnsson, Per,, Kienitz, Jens S., Kierspel, Thomas, Krasniqi, Faton, Kuehnel, Kai-Uwe, Kuepper, Jochen, Lund University., Maurer, Jochen, Messerschmidt, Marc, Moshammer, Robert, Mueller, Nele L. M., Rolles, Daniel, Rouzee, Arnaud, Rudek, Benedikt, Rudenko, Artem, Savelyev, Evgeny, Schlichting, Ilme, Schmidt, Carlo, Scholz, Frank, Schorb, Sebastian, Schulz, Joachim, Seltmann, Joern, Stapelfeldt, Henrik, Stener, Mauro, Stern, Stephan, Techert, Simone, Thogersen, Jan, Trippel, Sebastian, Ullrich, Joachim, Viefhaus, Jens, Vrakking, Marc   +52 more
core   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Unlocking the Power of Quercetin‐Encapsulated Mesoporous Bioactive Glass Nanoparticles: A Multifunctional Approach to Bone Regeneration

Advanced Engineering Materials, EarlyView.
Mesoporous bioactive glass nanoparticles (MBGNs) are investigated for bone regeneration given their remarkable structural and functional properties. MBGNs are functionalized with Mn and Cu and incorporated with quercetin, a natural flavonoid exhibiting antioxidant, anti‐inflammatory, and antimicrobial properties.
Giovanni Lo Bello, Qaisar Nawaz, Pier Francesco Ferrari, Laura Pastorino, Roberto Raiteri, Aldo R. Boccaccini   +5 more
wiley   +1 more source

Calculation of x-ray scattering patterns from nanocrystals at high x-ray intensity

Structural Dynamics, 2016
We present a generalized method to describe the x-ray scattering intensity of the Bragg spots in a diffraction pattern from nanocrystals exposed to intense x-ray pulses. Our method involves the subdivision of a crystal into smaller units.
Malik Muhammad Abdullah, Zoltan Jurek, Sang-Kil Son, Robin Santra   +3 more
doaj   +1 more source