Results 41 to 50 of about 140,342 (289)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Low emittance injector design for free electron lasers

Physical Review Special Topics. Accelerators and Beams, 2015
Several parameters determine the performance of free electron lasers: the slice and the projected emittance, the slice energy spread, and the peak current are the most crucial ones.
S. Bettoni, M. Pedrozzi, S. Reiche
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Laser phase errors in seeded free electron lasers

Physical Review Special Topics. Accelerators and Beams, 2012
Harmonic seeding of free electron lasers has attracted significant attention as a method for producing transform-limited pulses in the soft x-ray region. Harmonic multiplication schemes extend seeding to shorter wavelengths, but also amplify the spectral
D. Ratner, A. Fry, G. Stupakov, W. White
doaj   +1 more source

Three-dimensional analysis of the surface mode supported in \v{C}erenkov and Smith-Purcell free-electron lasers

, 2016
In \v{C}erenkov and Smith-Purcell free-electron lasers (FELs), a resonant interaction between the electron beam and the co-propagating surface mode can produce copious amount of coherent terahertz (THz) radiation.
Kalkal, Yashvir, Kumar, Vinit
core   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Real-time tracking of the intramolecular vibrational dynamics of liquid water

Communications Chemistry
Water’s polarity and hydrogen-bond network give rise to its unique chemical and biochemical behaviour. Its vibrational motions, occurring on a few-femtosecond timescale, govern ultrafast energy transfer within the hydrogen-bond network.
Gaia Giovannetti, Sergey Ryabchuk, Ammar Bin Wahid, Hui-Yuan Chen, Giovanni Batignani, Erik P. Månsson, Oliviero Cannelli, Emanuele Mai, Andrea Trabattoni, Ofer Neufeld, Angel Rubio, Vincent Wanie, Hugo Marroux, Tullio Scopigno, Majed Chergui, Francesca Calegari   +15 more
doaj   +1 more source

Formation of electron bunches for harmonic cascade x-ray free electron lasers

Physical Review Special Topics. Accelerators and Beams, 2006
Specific requirements for the electron beam in harmonic cascade-free electron lasers, together with means to produce such beams, are presented. All results are illustrated with simulations and particle tracking studies.
M. Cornacchia, S. Di Mitri, G. Penco, A. A. Zholents   +3 more
doaj   +1 more source

Radio-Frequency Undulators, Cyclotron Auto Resonance Maser and Free Electron Lasers

Applied Sciences, 2021
We discuss a hybrid Free Electron Laser (FEL) architecture operating with a RF undulator provided by a powerful Cyclotron Auto-Resonance Maser (CARM). We outline the design elements to operate a compact X-ray device.
Emanuele Di Palma, Silvio Ceccuzzi, Gian Luca Ravera, Elio Sabia, Ivan Spassovsky, Giuseppe Dattoli   +5 more
doaj   +1 more source