Results 151 to 160 of about 11,868,774 (305)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Read Me," Bookmark, Roseland Free Public Library, Ribbon-Cutting Ceremony (Roseland, N.J.), November 1, 1987

, 1987
Bookmark advertising the Ribbon Cutting Ceremony for the new Roseland Free Public Library on November 1 ...

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In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Child eating an ice pop, Anniversary Party for Kids, Roseland Free Public Library (Roseland, N.J.)

, 1997
Photo of kid having an ice pop, Anniversary Party for Kids, Roseland Free Public Library (Roseland, N.J.)

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Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A Newcastle disease outbreak in backyard and free-range poultry in Slovenia. [PDF]

Front Vet Sci
Žlabravec Z, Slavec B, Dovč A, Hari A, Račnik J, Wernig JM, Giussani E, Palumbo E, Varotto M, Monne I, Krapež U.   +10 more
europepmc   +1 more source

Gut impaction in free range hens

, 2015
This case study reports the outcome of an extreme overconsumption of pasture by free-range laying birds. It outlines the consequences of malnutrition due to animal behavior and housing condition in free-range laying hens, such as increased mortality and ...
Swick, Robert A, Choct, Mingan, Sommerlad, M, Ruhnke, Isabelle, Cowling, G   +4 more
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Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Insights into antibiotic resistomes from gut meta-genome-assembled genomes of the free-range chickens. [PDF]

Vet Anim Sci
Qi D, Liu J, Bai X, Chen B, Qiu F, Sun C, An J, Lai A, Li X.   +8 more
europepmc   +1 more source

Free Press birthday party photograph

, 1980
Photograph of two staff members during a party celebrating the 10th anniversary of the Free Press newspaper in Columbus, Ohio. The Columbus Free Press began as a bi-weekly publication in Columbus, Ohio, in 1970.
Bob Roehm (Photographer); Columbus Free Press (Publisher)
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