Results 81 to 90 of about 160,080 (300)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Developing an agro-forestry system for production of a commercial organic chicken flock focusing on profits on a 'Triple bottom Line' [PDF]

, 2006
In most modern free-range poultry systems birds do not fully utilise the range provided. Knowledge of the ancestral history of the domestic chicken, and research observations suggests benefits of agro-forestry systems for chickens.
Aspray, C, O'Brian, J, Philips, L
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Occurrence of Eimeria species parasites on small-scale commercial chicken farms in Africa and indication of economic profitability. [PDF]

, 2013
Small-scale commercial poultry production is emerging as an important form of livestock production in Africa, providing sources of income and animal protein to many poor households, yet the occurrence and impact of coccidiosis on this relatively new ...
Accra Vet Lab, Accra, Ghana, Awuni, J A, Blake, D P, Clark, E L, FAO - Rome, Fornace, K M, Karimuribo, E, LSHTM, Macdonald, S E, Namangala, B, Rushton, J, Southern African Ctr Infect Dis Surveillance, Thieme, O, Zambia   +13 more
core   +5 more sources

The productivity and financial impacts of eight types of environmental enrichment for broiler chickens [PDF]

, 2020
Reduced mobility in broilers can contribute to leg health problems. Environmental enrichment has been suggested as one approach to combat this through stimulating increased physical activity.
Jones, Philip J., Niemi, Jarkko K., Pedersen, Ida J., Riber, Anja B., Tahamtani, Fernanda M.   +4 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Pilot studies in organic broiler production – management and cross-breeds [PDF]

, 2002
Two pilot studies were conducted in 1999 and 2000, dealing with management strategies (study A) and alternative cross breeds (study B) in organic broiler production.
Bassler, Arnd, Ciszuk, Paul
core  

Eimeria species occurrence varies between geographic regions and poultry production systems and may influence parasite genetic diversity [PDF]

, 2017
Coccidiosis is one of the biggest challenges faced by the global poultry industry. Recent studies have highlighted the ubiquitous distribution of all Eimeria species which can cause this disease in chickens, but intriguingly revealed a regional divide in
A.S.R. Srinivasa Rao, Aarthi, Al-Natour, Arora, Awais, B. Chengat Prakashbabu, Blake, Blake, Bumstead, Chapman, Clark, D.G. Raj, D.P. Blake, Deichmann, E.L. Clark, F.M. Tomley, Fornace, G. Limon, Gharekhani, Graat, Grace, Haunshi, Henken, J. Guitian, Jadhav, Jatau, Jithendran, K. Kundu, Karthikeyan, Khan, Kumar, Kumar, Long, Long, Lunden, Luu, M. Raman, Mehta, P.S. Banerjee, R. Garg, Ramasamy, S. Kumar, Sharma, Shirzad, Srinivasa Rao, V. Thenmozhi, Williams, Williams, Williams, Williams   +49 more
core   +2 more sources