Results 91 to 100 of about 9,093,113 (302)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Aproximació al panorama actual de la reutilització de la informació del sector públic

open access: yesBiD: Textos Universitaris de Biblioteconomia i Documentació, 2012
A partir de les ponències de la II Jornada sobre la reutilización de la información del sector público, organitzada per les universitats Carlos III i Complutense de Madrid el febrer del 2012, s'analitza el marc legislatiu de la reutilització a Espanya ...
Valentín Ruiz, Francisco José   +1 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

O óbvio da informação científica: acesso e uso

open access: yesTransinformação
O texto aborda o acesso e o uso da informação científica, a partir da sua concepção e função para o avanço científico e tecnológico dos países. Na sociedade contemporânea, as redes eletrônicas de comunicação (ênfase para a Internet) agilizam o fluxo ...
Maria das Graças Targino
doaj  

La reutilització de la informació del sector públic a Espanya : una base sòlida per a un futur prometedor

open access: yesBiD: Textos Universitaris de Biblioteconomia i Documentació, 2012
La reutilització de la informació del sector públic és la base de les estratègies de dades obertes i de govern obert. Les autoritats europees fomenten polítiques de reutilització de la informació pública com un dels pilars de l'economia digital i una ...
García García, Emilio   +1 more
doaj   +1 more source

Decarboxylative Sulfinylation Enables a Direct, Metal-Free Access to Sulfoxides from Carboxylic Acids. [PDF]

open access: yesAngew Chem Int Ed Engl, 2022
Nguyen VD   +6 more
europepmc   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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