Results 81 to 90 of about 2,794,122 (314)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Towards implementing recognition of prior learning in the Free State Region [PDF]
, 2004 Published ArticleAccording to outcome 3 of the National Plan for Higher Education (2001: 28), recognition of prior learning (RPL) is an important avenue for increasing the intake of non-traditional students and adult learners.
Snyman, A.H.
core
FREE ACCESS TO JUSTICE AND PROCEDURAL LIABILITY
Revista Eletrônica de Direito Processual, 2018 The essay proposes a rational analysis of the procedural law wich grants free access to the legal system to those who can‟t afford it, proposing that the effects of the decision wich grants this benefit should be restricted in order to guarantee wide ...
Lucas Pahl Schaan Núñez
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The cost of universal free access for treating HIV/AIDS in low-income countries: the case of Senegal [PDF]
Since late 2003 in Senegal, voluntary tests, ARVs and CD4 counts have been provided free of charge by the State within the framework of public health services.
Vinard Philippe +2 more
core
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Study of the Publication Status of Scientific Journals in Iran [PDF]
تحقیقات اطلاعرسانی و کتابخانههای عمومی, 2011 Purpose: This study was performed to investigate the publication status of Iranian scientific journals with regard to scope, organizational affiliation, scientific level, publication language, electronic publication, and full-text access, either free or ...
Hossein Pashaeizad +2 more
doaj
Open and Free Access to Education for All [PDF]
, 2020 Open education has evolved over time and now has different interpretations. Three main versions of open education are considered, namely open universities, open educational resources (OER) and MOOCs. These all aim to increase access to education, but have different approaches for realising this aim.
openaire +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source