Results 91 to 100 of about 1,969,022 (331)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Analysis of the mushy region in conduction-convection problems with change of phase
Electronic Journal of Differential Equations, 1997 where convective motion of the liquid affects the change of phase. The mushy region is the portion of the system to which temperature and enthalpy do not assign a phase, solid or liquid. In this paper we show that the enthalpy density remains constant in
Mike O'Leary
doaj
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
On the motion of a viscous liquid with a free boundary
Учёные записки Казанского университета: Серия Физико-математические наукиThe problem of the non-stationary flow of a viscous liquid with an external free boundary around a moving solid cylindrical body was formulated and solved. The liquid is subject to periodic impacts with or without the predominant direction in space.
V. L. Sennitskii
doaj +1 more source
Thin circular plate uniformaly loaded over a concentric elliptic path and supported on columns
International Journal of Mathematics and Mathematical Sciences, 1986 Within the limitations of the classical thin plate theory expressions are obtained for the small deflections of a thin isotropic circular plate uniformly loaded over a concentric ellipse and supported by four columns at the vertices of a rectangle whose ...
W. A. Bassali
doaj +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Free boundary dimers: random walk representation and scaling limit. [PDF]
Probab Theory Relat Fields, 2023 Berestycki N, Lis M, Qian W.
europepmc +1 more source
The role of boundary conditions on the free surface of a liquid metal in an electrovortex flow
, 2021 I O Teplyakov +3 more
openalex +1 more source
Quantitative homogenization for the obstacle problem and its free boundary [PDF]
, 2021 Gohar Aleksanyan, Tuomo Kuusi
openalex +1 more source