Results 71 to 80 of about 271,727 (264)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Continuity of the free boundary in elliptic problems with Neuman boundary condition
Electronic Journal of Differential Equations, 2015 We show the continuity of the free boundary in a class of two dimensional free boundary problems with Neuman boundary condition, which includes the aluminium electrolysis problem and the heterogeneous dam problem with leaky boundary condition.
Abderachid Saadi
doaj
Thin circular plate uniformaly loaded over a concentric elliptic path and supported on columns
International Journal of Mathematics and Mathematical Sciences, 1986 Within the limitations of the classical thin plate theory expressions are obtained for the small deflections of a thin isotropic circular plate uniformly loaded over a concentric ellipse and supported by four columns at the vertices of a rectangle whose ...
W. A. Bassali
doaj +1 more source
Convergence of boundary integral method for a free boundary system
Journal of Computational and Applied Mathematics, 2018 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Wenrui Hao +3 more
openaire +3 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
On the motion of a viscous liquid with a free boundary
Учёные записки Казанского университета: Серия Физико-математические наукиThe problem of the non-stationary flow of a viscous liquid with an external free boundary around a moving solid cylindrical body was formulated and solved. The liquid is subject to periodic impacts with or without the predominant direction in space.
V. L. Sennitskii
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Boundary-value problem with free boundary: zirconium alloy hydrogenation
Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2016 One of the most important requirements for the reactor’s active zone materials (made of zirconium alloys) is low hydrogen absorptivity since hydrogen embrittlement may cause zirconium cladding damage.
Yury Zaika, Natalia Rodchenkova
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source