Results 61 to 70 of about 283,867 (316)

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Global Existence of Solutions to a Free Boundary Problem for Viscous Incompressible Magnetohydrodynamics for Small Data

open access: yesMathematics
The motion of viscous incompressible magnetohydrodynamics (MHD) is considered in a domain that is bounded by a free surface. The motion interacts through the free surface with an electromagnetic field located in a domain exterior to the free surface and ...
Piotr Kacprzyk   +1 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

A Diffusive Predator-Prey System with a Free Boundary

open access: yesVestnik KRAUNC: Fiziko-Matematičeskie Nauki
In this paper, we consider a problem with a free boundary for a diffusive predator-prey system in the onedimensional case. Nonlinear problems with free boundary are studied using a method based on constructing a priori estimates.
Rasulov, M.S., Jamoldinova, Sh.M.
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

open access: yesFEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez   +2 more
wiley   +1 more source

Continuity of the free boundary in elliptic problems with Neuman boundary condition

open access: yesElectronic Journal of Differential Equations, 2015
We show the continuity of the free boundary in a class of two dimensional free boundary problems with Neuman boundary condition, which includes the aluminium electrolysis problem and the heterogeneous dam problem with leaky boundary condition.
Abderachid Saadi
doaj  

Thin circular plate uniformaly loaded over a concentric elliptic path and supported on columns

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1986
Within the limitations of the classical thin plate theory expressions are obtained for the small deflections of a thin isotropic circular plate uniformly loaded over a concentric ellipse and supported by four columns at the vertices of a rectangle whose ...
W. A. Bassali
doaj   +1 more source

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