Results 51 to 60 of about 283,867 (316)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
A parabolic free boundary problem with Bernoulli type condition on the free boundary [PDF]
Journal für die reine und angewandte Mathematik (Crelles Journal), 2009 Consider the parabolic free boundary problem $$ Δu - \partial_t u = 0 \textrm{in} \{u>0\}, |\nabla u|=1 \textrm{on} \partial\{u>0\} . $$ For a realistic class of solutions, containing for example {\em all} limits of the singular perturbation problem $$Δu_ε- \partial_t u_ε= β_ε(u_ε) \textrm{as} ε\to 0,$$ we prove that one-sided flatness of the ...
Andersson, John, Weiss, Georg S.
openaire +3 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Quenching phenomenon of singular parabolic problems with L^1 initial data
Electronic Journal of Differential Equations, 2016 We extend some previous existence results for quenching type parabolic problems involving a negative power of the unknown in the equation to the case of merely integrable initial data. We show that $L^1(\Omega)$ is the suitable framework to obtain the
Anh Nguyen Dao +2 more
doaj
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Remarks on positive and free boundary solutions to a singular equation
Revista Integración, 2010 The equation −∆u = χ{u>0} − 1 uβ +λf(x, u) in Ω with Dirichlet boundary condition on ∂Ω has a maximal solution uλ ≥ 0 for every λ > 0. For λ less than a constant λ ∗ the solution vanishes inside the domain, and for λ > λ∗ the solution is ...
Juan Dávila, Marcelo Montenegro
doaj
The existence of axially symmetric stationary fluids with gravity
Advances in Nonlinear AnalysisWe establish a theoretical framework for the existence of axially symmetric stationary fluids with gravity within nozzles of finite height. The main focus is on the free streamline theory in axially symmetric fluids under the influence of gravity, with ...
Zhang Fan
doaj +1 more source
Periodic structures on liquid-phase smectic A, nematic and isotropic free surfaces
Beilstein Journal of Nanotechnology, 2018 The free boundary of smectic A (SmA), nematic and isotropic liquid phases were studied using a polarized optical microscope, an interferometric surface structure analyzer (ISSA), an atomic force microscope (AFM) and a scanning near-field optical ...
Anna N. Bagdinova +5 more
doaj +1 more source
Numerical Solution of a Free Boundary Problem from Heat Transfer by the Second Kind Chebyshev Wavelets [PDF]
Journal of Sciences, Islamic Republic of Iran, 2019 In this paper we reduce a free boundary problem from heat transfer to a weakly Singular Volterra integral equation of the first kind. Since the first kind integral equation is ill posed, and an appropriate method for such ill posed problems is based on ...
Bahman Babayar-Razlighi
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source