Results 41 to 50 of about 4,837,642 (257)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Direct numerical simulations of transition in a compressor cascade: The influence of free-stream turbulence [PDF]

, 2010
Copyright © Cambridge University Press 2010.The flow through a compressor passage without and with incoming free-stream grid turbulence is simulated.
TAMER A. ZAKI, Rodi, W, Durbin, PA, JAN G. WISSINK, WOLFGANG RODI, Wissink, JG, Zaki, TA, PAUL A. DURBIN   +7 more
core   +1 more source

General hyperbolic Kirchhoff model for the free vibration of elastic string on a flat surface

Applied Mathematics in Science and Engineering
In this work, we investigate the existence of weak solutions for the general form of the hyperbolic Kirchhoff-type problem involving a free boundary modelling the free vibration of an elastic string on a flat surface.
Fatima Ezahra Bentata, Ievgen Zaitsev
doaj   +1 more source

An Integral Equation Approach to the Irreversible Investment Problem with a Finite Horizon

Mathematics, 2020
This paper studies an irreversible investment problem under a finite horizon. The firm expands its production capacity in irreversible investments by purchasing capital to increase productivity.
Junkee Jeon, Geonwoo Kim
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A class of unstable free boundary problems [PDF]

, 2016
We consider the free boundary problem arising from an energy functional which is the sum of a Dirichlet energy and a nonlinear function of either the classical or the fractional perimeter.
Karakhanyan, Aram, S. Dipierro, Dipierro, Serena, Valdinoci, Enrico, Aram Karakhanyan, A. Karakhanyan, Serena Dipierro, Enrico Valdinoci, E. Valdinoci, E Valdinoci, S Dipierro, A Karakhanyan   +11 more
core   +1 more source

Quenching phenomenon of singular parabolic problems with L^1 initial data

Electronic Journal of Differential Equations, 2016
We extend some previous existence results for quenching type parabolic problems involving a negative power of the unknown in the equation to the case of merely integrable initial data. We show that $L^1(\Omega)$ is the suitable framework to obtain the
Anh Nguyen Dao, Jesus Ildefonso Diaz, Paul Sauvy   +2 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Remarks on positive and free boundary solutions to a singular equation

Revista Integración, 2010
The equation −∆u = χ{u>0} − 1 uβ +λf(x, u)
in Ω with Dirichlet boundary condition on ∂Ω has a maximal solution uλ ≥ 0 for every λ > 0. For λ less than a constant λ ∗ the solution vanishes inside the domain, and for λ > λ∗ the solution is ...
Juan Dávila, Marcelo Montenegro
doaj