Results 81 to 90 of about 271,727 (264)

Analysis of the mushy region in conduction-convection problems with change of phase

Electronic Journal of Differential Equations, 1997
where convective motion of the liquid affects the change of phase. The mushy region is the portion of the system to which temperature and enthalpy do not assign a phase, solid or liquid. In this paper we show that the enthalpy density remains constant in
Mike O'Leary
doaj  

Constraint Maps and Free Boundaries

Notices of the American Mathematical Society
In this survey we will focus on a specific but remarkably ubiquitous family of free boundary problems, those of obstacle-type. We will recount the historical development of the topic together with more recent advances, focusing in particular on vector-valued variational problems with constraints.
Figalli, Alessio, Guerra, André, Kim, Sunghan, Shahgholian, Henrik   +3 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Global fast and slow solutions of a single-species bacillus system with free boundary

Electronic Journal of Differential Equations, 2016
In this article, we consider a free boundary problem for a reaction diffusion equation which describes the dynamics of single bacillus population in higher space dimensions and heterogeneous environment.
Youpeng Chen, Xingying Liu, Lei Shi
doaj  

Well-posedness for physical vacuum free boundary problem of compressible Euler equations with time-dependent damping

Advances in Nonlinear Analysis
In this article, we consider the well-posedness of the local smooth solutions to the physical vacuum free boundary problem of the cylindrical symmetric Euler equations with time-dependent damping −μ(1+t)λρu-\frac{\mu }{{(1+t)}^{\lambda }}\rho {\bf{u}}, μ>
Li Haitong, Mai La-Su, Wang Shiyu
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

New Trends in Free Boundary Problems

Advanced Nonlinear Studies, 2017
We present a series of recent results on some new classes of free boundary problems.Differently from the classical literature, the problems considered have either a “nonlocal” feature (e.g., the interaction or/and the interfacial energy may depend on ...
Dipierro Serena, Karakhanyan Aram, Valdinoci Enrico   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source