Results 101 to 110 of about 4,837,642 (257)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Series 7: Press releases [PDF]

open access: yes, 1946
Series consists of a number of press releases regarding the upcoming Boundary Centennial ...

core  

C-infinity interfaces of solutions for one-dimensional parabolic p-Laplacian equations

open access: yesElectronic Journal of Differential Equations, 1999
We study the regularity of a moving interface $x = zeta (t)$ of the solutions for the initial value problem $$ u_t = left(|u_x|^{p-2}u_x ight)_x quad u(x,0) =u_0 (x),, $$ where $u_0in L^1({Bbb R})$ and $p>2$.
Yoonmi Ham, Youngsang Ko
doaj  

On guaranteed control of the parabolic obstacle problem

open access: yesЦифровые модели и решения
The article deals with the study on the issue of guaranteed control of parabolic differential equations with constraints related to obstacles at the system level.
Olga A. Nikishina, Tatyana V. Pyatkova
doaj   +1 more source

Free boundary methods and non-scattering phenomena. [PDF]

open access: yesRes Math Sci, 2021
Salo M, Shahgholian H.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

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