Results 101 to 110 of about 283,867 (316)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Convexity of the free boundary for an exterior free boundary problem involving the perimeter

open access: yes, 2010
We prove that if the given compact set $K$ is convex then a minimizer of the functional $$ I(v)=\int_{B_R} |\nabla v|^p dx+\text{Per}(\{v>0 ...
Mikayelyan, Hayk, Shahgholian, Henrik
openaire   +2 more sources

C-infinity interfaces of solutions for one-dimensional parabolic p-Laplacian equations

open access: yesElectronic Journal of Differential Equations, 1999
We study the regularity of a moving interface $x = zeta (t)$ of the solutions for the initial value problem $$ u_t = left(|u_x|^{p-2}u_x ight)_x quad u(x,0) =u_0 (x),, $$ where $u_0in L^1({Bbb R})$ and $p>2$.
Yoonmi Ham, Youngsang Ko
doaj  

On guaranteed control of the parabolic obstacle problem

open access: yesЦифровые модели и решения
The article deals with the study on the issue of guaranteed control of parabolic differential equations with constraints related to obstacles at the system level.
Olga A. Nikishina, Tatyana V. Pyatkova
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Free boundary methods and non-scattering phenomena. [PDF]

open access: yesRes Math Sci, 2021
Salo M, Shahgholian H.
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

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