Results 91 to 100 of about 1,973,708 (286)
Free boundary problems involving singular weights
, 2016 In this paper we initiate the investigation of free boundary minimization problems ruled by general singular operators with $A_2$ weights. We show existence and boundedness of minimizers.
Lamboley, Jimmy +2 more
core +3 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
MathematicsThe motion of viscous incompressible magnetohydrodynamics (MHD) is considered in a domain that is bounded by a free surface. The motion interacts through the free surface with an electromagnetic field located in a domain exterior to the free surface and ...
Piotr Kacprzyk +1 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
A Diffusive Predator-Prey System with a Free Boundary
Vestnik KRAUNC: Fiziko-Matematičeskie NaukiIn this paper, we consider a problem with a free boundary for a diffusive predator-prey system in the onedimensional case. Nonlinear problems with free boundary are studied using a method based on constructing a priori estimates.
Rasulov, M.S., Jamoldinova, Sh.M.
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Continuity of the free boundary in elliptic problems with Neuman boundary condition
Electronic Journal of Differential Equations, 2015 We show the continuity of the free boundary in a class of two dimensional free boundary problems with Neuman boundary condition, which includes the aluminium electrolysis problem and the heterogeneous dam problem with leaky boundary condition.
Abderachid Saadi
doaj
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source