Results 121 to 130 of about 11,289,377 (286)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
The Fourth Industrial Revolution – what does it mean to our future faculty?
South African Journal of Science, 2021 Vukosi Marivate +4 more
doaj +1 more source
Analysis of plant metabolomics data using identification‐free approaches
Applications in Plant SciencesPlant metabolomes are structurally diverse. One of the most popular techniques for sampling this diversity is liquid chromatography–mass spectrometry (LC‐MS), which typically detects thousands of peaks from single organ extracts, many representing true ...
Xinyu Yuan +2 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Research Advances in Free Cooling Technology of Data Centers
Zhileng xuebao, 2016 The increasing energy consumption of data centers attracts more and more attention, much of which is consumed by the cooling system. Utilizing efficient cooling methods is the urgent need for realizing emission control targets, and the free cooling is ...
Zhang Hainan +2 more
doaj
On computing eigensolution sensitivity data using free vibration solutions [PDF]
A simplified method of computing eigensolution sensitivity derivatives in structural dynamics is developed. It is shown that if the elements of stiffness and mass matrices associated with a design variable are homogeneous functions of that design ...
Wang, B. P.
core +1 more source
, 2006 The Web is an efficient way to disseminate all the data behind the conclusion given in a traditional journal documents which can provide to the user even complex data in a re-useable form but this is only useful if the data can be found and understood in context, with appropriate provenance, can be cited to a source with adequate version control and ...
openaire +1 more source