Results 71 to 80 of about 624,799 (321)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

High efficiency tapered free-electron lasers with a prebunched electron beam

Physical Review Accelerators and Beams, 2017
In this paper we analyze the high gain, high efficiency tapered free-electron laser amplifier with a prebunched electron beam. Simple scaling laws are derived for the peak output power and extraction efficiency and verified using 1D simulations.
C. Emma, N. Sudar, P. Musumeci, A. Urbanowicz, C. Pellegrini   +4 more
doaj   +1 more source

Compression of extreme-ultraviolet ultrashort pulses by grating configurations [PDF]

, 2015
The design and realization of grating instruments to condition the spectral phase of ultrashort extreme-ultraviolet pulses are discussed. The main application of such configurations is the temporal compression of pulses by compensating the phase chirp ...
Frassetto, Fabio, Miotti, Paolo, Poletto, Luca   +2 more
core   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Thermoreflectance Detection of Point Defects Resulting from Focused Ion Beam Milling

Advanced Engineering Materials, EarlyView.
Focused ion beam (FIB) milling is a common tool for nanoscale material processing, however irradiation damage, redeposition, and contamination can occur. We use several characterization tools to show FIB‐induced effects beyond 1 mm from the milled area.
Thomas W. Pfeifer, Eric R. Hoglund, Anton V. Ievlev, Patrick E. Hopkins   +3 more
wiley   +1 more source

Prevailing features of X-ray induced molecular electron spectra revealed with fullerenes

, 2014
Intense X-ray photo-absorption from short and intense pulses by a molecule triggers complicated electron and subsequently ion dynamics leading to photo-electron spectra which are difficult to interpret.
Garibay, Abraham Camacho, Rost, Jan M., Saalmann, Ulf   +2 more
core   +1 more source

Toward atomic resolution diffractive imaging of isolated molecules with X-ray free-electron lasers. [PDF]

Faraday discussions, 2014
We give a detailed account of the theoretical analysis and the experimental results of an X-ray-diffraction experiment on quantum-state selected and strongly laser-aligned gas-phase ensembles of the prototypical large asymmetric rotor molecule 2,5 ...
S. Stern, L. Holmegaard, F. Filsinger, Arnaud Rouz'ee, Artem Rudenko, Per Johnsson, Andrew V. Martin, A. Barty, C. Bostedt, J. Bozek, R. Coffee, S. Epp, B. Erk, L. Foucar, R. Hartmann, N. Kimmel, Kai-Uwe Kuhnel, Jochen Maurer, Marc Messerschmidt, B. Rudek, D. Starodub, J. Thøgersen, G. Weidenspointner, T. A. White, Henrik Stapelfeldt, D. Rolles, H. Chapman, J. Kupper   +27 more
semanticscholar   +1 more source

Low‐Cost, Large‐Scale Nanoporous Metals by Mechanical Alloying, Oxide Reduction, and Dealloying of Powders

Advanced Engineering Materials, EarlyView.
Powder metal processing provides scalable advantages in nanoporous (np) metal development. Mechanical alloying is used to produce unique precursors for hybrid nanopore formation by oxide reduction and dealloying. As demonstrated in np Ag, this approach improves process efficiency while promoting smaller ligaments and larger pores, both of which are ...
Mark A. Atwater, Oliver A. Fowler
wiley   +1 more source

Model-based optimization of tapered free-electron lasers

Physical Review Special Topics. Accelerators and Beams, 2015
The energy extraction efficiency is a figure of merit for a free-electron laser (FEL). It can be enhanced by the technique of undulator tapering, which enables the sustained growth of radiation power beyond the initial saturation point.
Alan Mak, Francesca Curbis, Sverker Werin   +2 more
doaj   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source