Results 61 to 70 of about 596,723 (309)

Application of the scaled quasi-free scattering model absorption potential to electron scattering by CHx (x=1,2,3,4)

, 2015
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)In this work the newly derived scaling quasi-free scattering model (SQFSM) absorption potential is applied to electron-CHx (x=
Brescansin, LM, Machado, LE, Lee, MT, Souza, GLC, Castro, EAY, dos Santos, AS   +5 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The detrimental effect of spontaneous emission in quantum free electron lasers : a discrete Wigner model [PDF]

, 2018
We study the spontaneous emission in high-gain free-electron lasers operating in the quantum regime and its detrimental effect on coherent emission.
Piovella, N., Robb, G. R. M., G. R. M. Robb, H. Fares, Fares, H., N. Piovella   +5 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A reduced model for relativistic electron beam transport in solids and dense plasmas

New Journal of Physics, 2014
A hybrid reduced model for relativistic electron beam transport based on the angular moments of the relativistic kinetic equation with a special closure is presented. It takes into account collective effects with the self-generated electromagnetic fields
M Touati, J-L Feugeas, Ph Nicolaï, J J Santos, L Gremillet, V T Tikhonchuk   +5 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Analysis of two-color photoelectron spectroscopy for attosecond metrology at seeded free-electron lasers

New Journal of Physics, 2021
The generation of attosecond pulse trains at free-electron lasers opens new opportunities in ultrafast science, as it gives access, for the first time, to reproducible, programmable, extreme ultraviolet (XUV) waveforms with high intensity.
P K Maroju, C Grazioli, M Di Fraia, M Moioli, D Ertel, H Ahmadi, O Plekan, P Finetti, E Allaria, L Giannessi, G De Ninno, S Spampinati, A A Lutman, R J Squibb, R Feifel, P Carpeggiani, M Reduzzi, T Mazza, M Meyer, S Bengtsson, N Ibrakovic, E R Simpson, J Mauritsson, T Csizmadia, M Dumergue, S Kühn, N G Harshitha, D You, K Ueda, M Labeye, J E Bækhøj, K J Schafer, E V Gryzlova, A N Grum-Grzhimailo, K C Prince, C Callegari, G Sansone   +36 more
doaj   +1 more source

Nonlinear mode coupling in free electron lasers [PDF]

, 1993
The optical field in free electron lasers can sometimes develop sidebands and exhibit very complex behavior. The purpose of this report is to develop a two mode model of the optical field in a free electron laser in which the optical modes are coupled by
Frenzen, Christopher L., C. L. Frenzen
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source