Results 91 to 100 of about 5,253,595 (284)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Rotation of Galaxies within Gravity of the Universe
Entropy, 2016 Rotation of galaxies is examined by the general principle of least action. This law of nature describes a system in its surroundings, here specifically a galaxy in the surrounding Universe.
Arto Annila
doaj +1 more source
Effective Free Energy for Individual Dynamics
, 2011 Physics and economics are two disciplines that share the common challenge of linking microscopic and macroscopic behaviors. However, while physics is based on collective dynamics, economics is based on individual choices.
Anderson S. P. +7 more
core +2 more sources
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Brain activity and cognition: A connection from thermodynamics and information theory
Frontiers in Psychology, 2015 The connection between brain and mind is an important scientific and philosophical question that we are still far from completely understanding. A crucial point to our work is noticing that thermodynamics provides a convenient framework to model brain ...
Guillem eCollell, Jordi eFauquet
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
The computational anatomy of psychosis
Frontiers in Psychiatry, 2013 This paper considers psychotic symptoms in terms of false inferences or beliefs. It is based on the notion that the brain is an inference machine that actively constructs hypotheses to explain or predict its sensations.
Rick A Adams +6 more
doaj +1 more source
Shape dependent finite-size effect of critical two-dimensional Ising model on a triangular lattice
, 2012 Using the bond-propagation algorithm, we study the finite-size behavior of the critical two-dimensional Ising model on a finite triangular lattice with free boundaries in five shapes: triangle, rhombus, trapezoid, hexagon and rectangle. The critical free
Guo, Wenan +2 more
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
, 2013 We derive some exact bounds on the free energy $W(J)$ in QCD, where $J_\mu^b$ is a source for the gluon field $A_\mu^b$ in the minimal Landau gauge, and $W(J)$ is the generating functional of connected gluon correlators. Among other results, we show that
Maas, Axel, Zwanziger, Daniel
core +1 more source