Results 61 to 70 of about 1,381,598 (313)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Shipin yu jixieObjectiveTo propose a method for modifying the existed isotherm model based on molecular thermodynamics.MethodsThe phantom model in polymer physics field was borrowed to predict the chemical potential of water from swelling effect.
ZHAO Xuewei +4 more
doaj +1 more source
A Complexity Science Account of Humor
Entropy, 2023 A common assumption of psychological theories of humor is that experienced funniness results from an incongruity between stimuli provided by a verbal joke or visual pun, followed by a sudden, surprising resolution of incongruity.
Wolfgang Tschacher, Hermann Haken
doaj +1 more source
CoRRStandard attention stores keys/values losslessly but reads them via a per-head convex average, blocking channel-wise selection. We propose the Free Energy Mixer (FEM): a free-energy (log-sum-exp) read that applies a value-driven, per-channel log-linear tilt to a fast prior (e.g., from queries/keys in standard attention) over indices.
Jiecheng Lu, Shihao Yang
openaire +2 more sources
THE FREE ENERGY OF BIOLOGICAL PROCESSES [PDF]
Journal of General Physiology, 1920 n ...
openaire +2 more sources
Free energy calculations of glycosaminoglycan - Protein interactions
, 2009 Glycosaminoglycans (GAGs) are complex highly charged linear polysaccharides that have a variety of roles in biological processes. We report the first use of molecular dynamics (MD) free energy calculations using the MM/PBSA method to investigate the ...
Ricardo L Mancera +5 more
core +1 more source
A Benchmark of Electrostatic Methods Performance in Relative Binding Free Energy Calculations
, 2021 Relative free energy calculations are fast becoming a critical part of early stage pharmaceu- tical design, making it important to know how to obtain the best performance with these calculations in applications which could span hundreds of calculations ...
David, Mobley +2 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Atomistic simulation of voltage activation of a truncated BK channel
eLifeVoltage-dependence gating of ion channels underlies numerous physiological and pathophysiological processes, and disruption of normal voltage gating is the cause of many channelopathies.
Zhiguang Jia, Jianhan Chen
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source