Results 71 to 80 of about 5,248,562 (283)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Brain asymmetry as minimization of free energy: a theoretical model

Royal Society Open Science
The asymmetry between the left and right sides seems to be a general principle of organization of the nervous systems in Bilateria, providing the foundations for a plethora of leftward and rightward biases in behaviour as documented in species ranging ...
Giorgio Vallortigara, Giuseppe Vitiello
doaj   +1 more source

Exploration, Novelty, Surprise and Free Energy Minimisation

Frontiers in Psychology, 2013
This paper reviews recent developments under the free energy principle that introduce a normative perspective on classical economic (utilitarian) decision-making based on (active) Bayesian inference.
Philipp eSchwartenbeck, Thomas eFitzGerald, Ray eDolan, Karl eFriston   +3 more
doaj   +1 more source

Molecular model of OCP-phycobilisome complex formation [PDF]

Компьютерные исследования и моделирование, 2014
A molecular model of phicobilisome complex with a quenching protein OCP which regulates the energy transfer from phicobilisome to photosystem in photosynthetic apparatus of cyanobacteria has been developed.
P. M. Krasilnikov, Igor Nikolaevich Stadnichuk, D. V. Zlenko   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Bubble Free Energy in Cosmological Phase Transitions

, 1993
Free energy as a function of temperature and the bubble radius is determined for spherical bubbles created in cosmological first order phase transitions. The phase transition is assumed to be driven by an order parameter (e.g. a Higgs field) with quartic
Anderson, Csernai, Dine, Enqvist, J Ignatius, Kajantie, Kajantie, Kamionkowski, Lana, Linde, Liu, Madsen, Mardor, McLerran, Navascués, Rowlinson, Turok   +16 more
core   +3 more sources

Free Energy Guided Sampling [PDF]

Journal of Chemical Theory and Computation, 2012
A free energy-guided sampling (FEGS) method is proposed for accelerating exploration of conformational space in unbiased molecular dynamics. Using the cut-based free energy profile and Markov state models, FEGS speeds up sampling of the canonical ensemble by iteratively restarting multiple short simulations in parallel from regions of the free energy ...
Ting, Zhou, Amedeo, Caflisch
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Free energy and dendritic self-organisation

Frontiers in Systems Neuroscience, 2011
In this paper, we pursue recent observations that, through selective dendritic filtering, single neurons respond to specific sequences of presynaptic inputs.
Stefan J Kiebel, Karl J Friston
doaj   +1 more source