Results 41 to 50 of about 1,552,141 (263)
Question, 2014 El trabajo repasa las alternativas de la creación y el desarrollo de la agencia de noticias TÉLAM, órgano de difusión de noticias oficial del Estado argentino fundada en 1945 por impulso del entonces hombre fuerte del Gobierno nacional, el Coronel Juan ...
Lisandro Sabanés
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Growth Opportunities, Earning Permanence and the Valuation of Free Cash Flow [PDF]
راهبرد مدیریت مالی, 2017 Equity Valuation Theory prescribes that free cash flow should not be associated with stock returns because it does not add value. However, free cash flow could become a value-relevant construct in certain contexts.
Seyed Mojtaba Hoseini +3 more
doaj +1 more source
Free surface flows : coalescence, spreading and dewetting [PDF]
, 2014 Capillary and wetting phenomena are an essential part of nature. Its presence is noticed in many circumstances where solid and liquid surfaces come into contact. In this thesis different types of capillary free surface flows are studied. The topics discussed are mainly the coalescence of viscous sessile drops, the Marangoni-spreading of locally ...
openaire +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Free Cash Flow Valuation Model in Capital Budgeting [PDF]
European Project Management Journal, 2017 Modern performance measures should provide an accurate assessment of the intrinsic value of the company, as well as the value for the owners (shareholders). The essence is maximizing the immanent or guaranteed value of the company.
Ivana Bešlić Rupić +2 more
doaj
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Journal of Hydrology and HydromechanicsIn this paper, the scour downstream of a trapezoidal Piano key weir (PKW) is investigated under free and submerged flow conditions. For this purpose, an experimental model was used in a laboratory channel with a length of 10 m, width of 0.75 m, and ...
Bodaghi Elnaz +2 more
doaj +1 more source