Results 231 to 240 of about 1,276,041 (313)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

A theoretical study on the feasibility of 1,4-Copper migration in the Cu-catalyzed formal hydro(borylmethylsilyl)ation of internal alkynes. [PDF]

Commun Chem
Liu S, Chen W, Long X, Zhang D, Chen J, Zhu Z, Wei H.   +6 more
europepmc   +1 more source

Bun quality gluten free base co-products rice and soybean with hydrocolloids and or transglutaminase

, 2015
Kátia Maria Marques Sousa de Deus
openalex   +1 more source

Consumption of gluten free products increases heavy metal intake

, 2018
Julia Wünsche, Christine Lambert, Ute Gola, Hans K. Biesalski   +3 more
openalex   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Diastereoselective Synthesis of <i>cis</i>-α,α'-Disubstituted Cyclic Ethers via Borane-Catalyzed Reductive Cyclization of Diketones. [PDF]

ACS Catal
Shcherbakov NV, Potin N, Mas-Roselló J.
europepmc   +1 more source

Synergistic removal of pesticides and transformation products through optimization of ozonation and granular activated carbon filtration parameters toward achieving toxin-free drinking water

Wenling Shi, Yu Cheng, Xinhua Li, Xue Zhang, Hongjiao Pang, Chengzhi Hu, Chengzhi Hu   +6 more
openalex   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Responses to e-cigarette nicotine source descriptors: results from a randomised experiment. [PDF]

Tob Control
Seidenberg AB, Azadi M, Silver NA, D'Esterre AP, Kaufman A, Mayne RG, Roditis M, Heley K, Kreslake JM.   +8 more
europepmc   +1 more source