Results 81 to 90 of about 4,966,064 (325)
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Novel and unscrutinized immune entities of the zebrafish gut
FEBS Letters, EarlyView.Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil +5 more
wiley +1 more source
Tetrahedral chains and a curious semigroup
Extracta Mathematicae, 2019 In 1957 Steinhaus asked for a proof that a chain of identical regular tetrahedra joined face to face cannot be closed. Świerczkowski gave a proof in 1959.
Ian Stewart
doaj
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Projections in free product C*-algebras, II
, 1999 Let (A,phi) be the reduced free product of infinitely many pairs (A_i,phi_i) of C*-algebras with faithful states. Assume that the A_i are not too small, in a specific sense. It is shown that if phi is a trace then K_0(A) is determined entirely by K_0(phi)
Dykema, Ken, Rordam, Mikael
core +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
On the Root-Class Residuallity of Generalized Free Products
Моделирование и анализ информационных систем, 2013 Let K be a root class of groups. It is proved that a free product of any family of residually K groups with one amalgamated subgroup, which is a retract in all free factors, is residually K.
E. A. Tumanova
doaj +3 more sources
Russian Journal of Agricultural and Socio-Economic Sciences, 2020 This study aims to acknowledge and find empirical evidence of the effect of food crop production on gross domestic product and producer prices on cost insurance, freight, imports and free on board.
Hartati S.
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source