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The anticonvulsant zonisamide scavenges free radicals
Epilepsy Research, 1998Zonisamide (ZNS) is effective in animal models of epilepsy and epileptic patients. The free radical scavenging activities of ZNS were analyzed by using electron spin resonance. ZNS, in the mmolar range, scavenged hydroxyl and nitric oxide radicals in a dose-dependent manner.
Lester Packer, Yasuko Noda, Akitane Mori
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Free radical‐scavenging properties of lignin
Nutrition and Cancer, 1998Lignin is one of the major components of dietary fiber. It is a complex hydrophobic molecule that typically occurs in cell walls with heteroxylans. Our experimental data show that lignin is a free radical scavenger. When the NADH-phenazine methosulfate-nitro blue tetrazolium free radical-producing system is used, an alkali-lignin concentration of 46.29
Li‐Hsueh Chu +2 more
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Copper or free radical scavenger?
Computational and Theoretical Chemistry, 2017Abstract Free radicals are very reactive molecules that produce so-called oxidative stress. To prevent oxidative stress there are two types of molecules: primary and secondary antioxidants. The chelation of copper is an example of a secondary antioxidant process. Therefore, these secondary antioxidants can be named copper scavengers. The main purpose
Miguel Reina, Ana Martínez
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Carnitine as a free radical scavenger in aging
Experimental Gerontology, 2001Carnitine (4-N-trimethylammonium-3-hydroxybutyric acid) plays an important role in the translocation of acetyl moieties from the mitochondria into the cytoplasm for acetylcholine synthesis in the brain. Previous studies in our laboratory have shown that L-carnitine suppresses oxidative damage during aging.
Chinnakkannu Panneerselvam +1 more
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Free Radicals and Their Scavengers in Parkinson’s Disease
European Neurology, 1993In recent years, it has been shown that active oxygen species or free radicals are closely involved in various diseases. Accumulating information supports the hypothesis that oxidative stress involving lipid peroxidation may contribute to the pathogenesis of Parkinson's disease.
T. Yoshikawa, T. Yoshikawa
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Free Radical Scavenging Properties of Sulfinpyrazone
Free Radical Research, 2002Sulfinpyrazone, a potent uricosuric drug, was tested in vitro for its scavenging action against oxygen free radicals. In this study, sulfinpyrazone was able to scavenge 1,1-diphenyl-2-picrylhydrazyl radical with IC50 value of 29.82 micrograms/ml compared to butylated hydroxytoluene (BHT, IC50 value = 20.15 micrograms/ml) and Trolox (IC50 value = 16.01 ...
Yashang Lee +3 more
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Allantoin as a free-radical scavenger.
Doklady. Biochemistry and biophysics, 2002In vertebrates, free purine bases are deaminated mainly to hypoxantine (Ia) or xantine (Ib), which are further oxidized to uric acid (Ic) in the presence of oxygen. Its further conversion (Ic to If) is shown in the following scheme:
E. P. Gus'kov +7 more
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Free Radical Scavenging Action of Baicalein
Archives of Biochemistry and Biophysics, 1993TJ-960 is a Japanese Kampo (traditional herbal) medicine used for the treatment of epilepsy. It's a crude drug, an extract of nine herbs, and consists of many known and unknown components. Among the known components of TJ-960, we found that 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one (baicalein) might be the most potent scavenger for radicals.
H. Hamada +3 more
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Modulation of platelet function by free radicals and free-radical scavengers
Trends in Pharmacological Sciences, 1993Platelets have the capacity to generate oxygen-derived free radicals and are often present at inflammatory foci with other free-radical-generating cells such as white blood cells. Free radicals can modify platelet adhesion and aggregation directly or through effects on the vascular endothelium, which generates prostacyclin and nitric oxide.
Daniela Salvemini, Regina M. Botting
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The Significance of Free Radicals and Free Radical Scavengers in L1210 Leukemia
1988L1210 leukemia is a murine leukemia which is associated with anemia and marked neutrophilia. In order to determine the significance of free radicals (FR) in this disorder, we determined the presence and localization of free radical scavengers (FRS) and scavenger-like systems in L1210 leukemia cells obtained in vivo and from in vitro cultures.
J. D. Lutton, A. C. Brown
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