Results 261 to 270 of about 5,663,581 (403)

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Hydroxyl radical generation from environmentally persistent free radicals (EPFRs) in PM2.5.

Environmental Science and Technology, 2014
William Gehling, L. Khachatryan, B. Dellinger   +2 more
semanticscholar   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Enhanced Gamma Ray Radiation Resistance of Silicone Elastomers via Trace Addition of Perovskite Nanocrystals for Free Radicals Scavenging. [PDF]

Small Sci
Zheng W, Han X, Hao J, Liu H, Long T, Zhu L, Lu H, Wang H, Yu WW, Zhou C.   +9 more
europepmc   +1 more source

On the nature of free radicals induced by X-rays in puric bases.

, 1967
Monique Lacroix, J. Depireux, A. Van de Vorst   +2 more
openalex   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Chemical Composition, Free Radicals and Pathogenic Microbes in the Extract Derived from Dictyota dichotoma: In Silico and In Vitro Approaches. [PDF]

Mar Drugs
Oumassi F, Chebbac K, Ben Ali N, Kaabi S, El Ansari ZN, Metouekel A, El Barnossi A, El Moussaoui A, Chebaibi M, Bounab L, Mssillou I, Shahat AA, El Bouzdoudi B, L'bachir El Kbiach M.   +13 more
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

AhR Activation at the Air-Blood Barrier Alters Systemic microRNA Release After Inhalation of Particulate Matter Containing Environmentally Persistent Free Radicals. [PDF]

Cardiovasc Toxicol
Aryal A, Harmon AC, Noël A, Yu Q, Varner KJ, Dugas TR.   +5 more
europepmc   +1 more source

ELECTRON SPIN RESONANCE OF FREE RADICALS IN PERHYDROTRIPHENYLENE INCLUSION COMPOUNDS

, 1965
O. Hayes Griffith
openalex   +1 more source