Results 271 to 280 of about 320,731 (312)
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Journal of Pharmacological and Toxicological Methods, 1993
Because of the molecular configuration, most free radicals are highly reactive and can cause cell injury. Protective mechanisms have evolved to provide defense against free-radical injury. Any time these defense systems are overwhelmed, such as during disease states, cell dysfunction may occur.
N, Kaul +4 more
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Because of the molecular configuration, most free radicals are highly reactive and can cause cell injury. Protective mechanisms have evolved to provide defense against free-radical injury. Any time these defense systems are overwhelmed, such as during disease states, cell dysfunction may occur.
N, Kaul +4 more
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Free Radicals and Carcinogenesis
Free Radical Research Communications, 1990The role of free radicals and active states of oxygen in human cancer is as yet unresolved. Various lines of evidence provide strong but inferential evidence that free radical reactions can be of crucial importance in certain carcinogenic mechanisms. A central point in considering free radical reactions in carcinogenesis is that human cancer is really ...
B D, Goldstein, G, Witz
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Modulation of platelet function by free radicals and free-radical scavengers
Trends in Pharmacological Sciences, 1993Platelets have the capacity to generate oxygen-derived free radicals and are often present at inflammatory foci with other free-radical-generating cells such as white blood cells. Free radicals can modify platelet adhesion and aggregation directly or through effects on the vascular endothelium, which generates prostacyclin and nitric oxide.
D, Salvemini, R, Botting
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The need for a ?free radical initiative'
Diabetologia, 1996The article presented by Drs. Paolisso and Giugliano discusses the possible relationship between oxidative stress and insulin action. The hypothesis formulated by the authors is that oxidative stress can impair insulin action through a change in the physical state of the plasma membrane of target cells, an increase in intracellular calcium content and ...
COMINACINI, Luciano +2 more
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Photoionization of Free Radicals
International Journal of Radiation Applications and Instrumentation. Part C. Radiation Physics and Chemistry, 1974Since this is the first lecture at this Institute on photoionization and free radicals, permit me to take a few minutes to outline my concept of these terms.
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Seminars in Reproductive Medicine, 1998
Partial reduction of molecular oxygen can generate reactive oxygen species (ROS), including the hydrogen peroxide, and the free radicals superoxide and hydroxyl. The formation of ROS is a feature of many degenerative diseases, such as atherosclerosis and neurodegeneration, Organisms contain a battery of defense mechanisms to prevent the formation of ...
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Partial reduction of molecular oxygen can generate reactive oxygen species (ROS), including the hydrogen peroxide, and the free radicals superoxide and hydroxyl. The formation of ROS is a feature of many degenerative diseases, such as atherosclerosis and neurodegeneration, Organisms contain a battery of defense mechanisms to prevent the formation of ...
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Trends in Neurosciences, 2004
Aging is characterized by decrements in maximum function and accumulation of mitochondrial DNA mutations, which are best observed in organs such as the brain that contain post-mitotic cells. Oxygen radicals are increasingly considered responsible for part of these aging changes.
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Aging is characterized by decrements in maximum function and accumulation of mitochondrial DNA mutations, which are best observed in organs such as the brain that contain post-mitotic cells. Oxygen radicals are increasingly considered responsible for part of these aging changes.
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1986
It is now clear that free radical intermediates often are involved in the activation of many types of procarcinogens and promutagens to their active forms as well as in the binding of these activated species to DNA. In this chapter, a general introduction to free radical chemistry is presented, with some discussion of radical lifetimes and reactivities.
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It is now clear that free radical intermediates often are involved in the activation of many types of procarcinogens and promutagens to their active forms as well as in the binding of these activated species to DNA. In this chapter, a general introduction to free radical chemistry is presented, with some discussion of radical lifetimes and reactivities.
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The Significance of Free Radicals and Free Radical Scavengers in L1210 Leukemia
1988L1210 leukemia is a murine leukemia which is associated with anemia and marked neutrophilia. In order to determine the significance of free radicals (FR) in this disorder, we determined the presence and localization of free radical scavengers (FRS) and scavenger-like systems in L1210 leukemia cells obtained in vivo and from in vitro cultures.
A C, Brown, J D, Lutton
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Mutation Research/DNAging, 1992
Free radical reactions are ubiquitous in living things. Studies on the origin and evolution of life provide a reasonable explanation for the prominent presence of this unruly class of chemical reactions. These reactions have been implicated in aging.
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Free radical reactions are ubiquitous in living things. Studies on the origin and evolution of life provide a reasonable explanation for the prominent presence of this unruly class of chemical reactions. These reactions have been implicated in aging.
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