Results 101 to 110 of about 4,892,815 (298)

Comentaris breus sobre la GNU General Public License v3

open access: yesIDP, 2009
La llicència GNU General Public License és la llicència de programari lliure més utilitzada i constitueix un document fonamental per al moviment de programari lliure.
Malcolm Bain
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

The Problem of Computer Piracy [PDF]

open access: yes, 2017
The problem of illegal downloading is widely spread in the modern world. There are various reasons lying behind the desire to get some paid software or programs free of charge.
Alekseev, A. M.   +2 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Open software in small enterprises. Private medical practise example

open access: yesContemporary Economy, 2011
Article covers basic concepts of free and open software and its implementation at small health care facilities. It summarizes costs of possession and maintenance free/open and proprietary software.
Dominik Meller
doaj  

Creation and Validation of Chronojump-Boscosystem: A Free Tool to Measure Vertical Jumps. (Creación y validación de Chronojump-Boscosystem: un instrumento libre para la medición de saltos verticales).

open access: yesRevista Internacional de Ciencias del Deporte, 2012
Measuring the height of the vertical jump is an indicator of the strength and power of the lower body. The technological tools available to measure the vertical jump are black boxes and are not open to third-party verification or adaptation.
José Luis López del Amo   +3 more
doaj   +1 more source

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