Results 101 to 110 of about 2,007,881 (314)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Revista Cubana de Investigaciones Biomédicas, 2010 Con el fin de estimular el uso de R en la investigación clínica y a partir de la experiencia con este software para el procesamiento y análisis de datos, se muestran algunas de sus características y las principales ventajas que ofrece su utilización en ...
MayelÍn Mirabal Sosa +2 more
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Structure-based drug design of an inhibitor of the SARS-CoV-2 (COVID-19) main protease using free software: A tutorial for students and scientists. [PDF]
Eur J Med Chem, 2021 Zhang S +5 more
europepmc +1 more source
Sampling Process Model for Coordination and Communication in Free/Open Source Software Projects
, 2014 Preet Kanwal, Anu Gupta, R. K. Singla
openalex +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Revista Fuentes El Reventón Energético, 2009 This paper shows the implementation of a neurosimulation technique for the well placement applied to the development of a heterogeneous hydrocarbon field with an irregular geometry.
Elkin Rodolfo Santafe Rangel +1 more
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