Results 121 to 130 of about 2,170,936 (313)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A Semi-Automatic Method to Create an Affordable Three-Dimensional Printed Splint Using Open-Source and Free Software. [PDF]

Cureus, 2021
Wang Z, Dubrowski A.
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Decoding the "Free/Open Source(F/OSS) Software Puzzle" a survey of theoretical and empirical contributions [PDF]

F/OSS software has been described by many as a puzzle. In the past five years, it has stimulated the curiosity of scholars in a variety of fields, including economics, law, psychology, anthropology and computer science, so that the number of ...
Maria Alessandra Rossi
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Free Open Source Software and Dual-Use: Loophole or Dissent?

, 2011
The Free Open Source Software (FOSS) seem far from the military field but in some cases, some technologies normally used for civilian purposes may have military applications. These products and technologies are called dual-use.
Foutel, Nathalie
core  

Diferentes, desiguales y desconectadas . ¿Quién es quién en las industrias tecnológicas? / Different, unequal and disconnected . Who’s who in the technological industries?

Asparkía, 2011
RESUMEN: Este artículo pretende enfocar cuál es el lugar de las mujeres en las industrias tecnológicas. Sabemos que el núcleo duro de la equidad de género sigue siendo lo económico, cuyo sistema sexo/género sostiene la relación del ámbito productivo y ...
Ana Navarrete Tudela
doaj  

In Silico Approach Using Free Software to Optimize the Antiproliferative Activity and Predict the Potential Mechanism of Action of Pyrrolizine-Based Schiff Bases. [PDF]

Molecules, 2021
Almalki FA, Abdalla AN, Shawky AM, El Hassab MA, Gouda AM.   +4 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

From Normal Business to Financial Crisis ... and Back Again. An Illustration of the Benefits of Cassandre for Qualitative Analysis

Forum: Qualitative Social Research, 2011
Cassandre is a free open source text analysis software tool. It uses semi-automatic coding, based on the identification of markers, grouped into registers, which represent analysis categories. Studying the causes of the financial crisis makes it possible
Christophe Lejeune
doaj