Results 141 to 150 of about 2,170,936 (313)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Selection and Management of Open Source Software in Libraries

, 2007
Open source software was a revolutionary concept among computer programmers and users. To a certain extent open source solutions could provide an alternative solution to costly commercial software.
Vimal Kumar, V.
core  

R: una herramienta poco difundida y muy útil para la investigación clínica R: a not much spread and very useful tool for clinical research

Revista Cubana de Investigaciones Biomédicas, 2010
Con el fin de estimular el uso de R en la investigación clínica y a partir de la experiencia con este software para el procesamiento y análisis de datos, se muestran algunas de sus características y las principales ventajas que ofrece su utilización en ...
MayelÍn Mirabal Sosa, Maytee Robaina García, Rolando Uranga Piña   +2 more
doaj  

SSD - a free software for designing multimeric mono-, bi- and trivalent shRNAs. [PDF]

Genet Mol Biol, 2020
Carli GJ, Rotela AT, Lubini G, Contiliani DF, Candia NB, Depintor TS, Abreu FCP, Simões ZLP, Ríos DF, Pereira TC.   +9 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

USO DE NEUROSIMULACIÓN EN EL POSICIONAMIENTO DE POZOS DURANTE EL DESARROLLO DE UN CAMPO DE HIDROCARBUROS

Revista Fuentes El Reventón Energético, 2009
This paper shows the implementation of a neurosimulation technique for the well placement applied to the development of a heterogeneous hydrocarbon field with an irregular geometry.
Elkin Rodolfo Santafe Rangel, Hector Emiliano Barrios Molano   +1 more
doaj  

CroSSED sequence, a new tool for 3D processing in geosciences using the free software 3DSlicer. [PDF]

Sci Data, 2020
Dorador J, Rodríguez-Tovar FJ.
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Some Policy Issues on Open Source and Proprietary Software [PDF]

Software industry is a fast growing sector of the economy which is undergoing significant changes both for the presence of the open source mode of production and for the challenges of globalization and convergence with other industries.
Graziella Marzi
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source