Results 131 to 140 of about 2,170,936 (313)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
SimCode: Agent-based Simulation Modelling of Open-Source Software Development [PDF]
We present an original modeling tool, which can be used to study the mechanisms by which free/libre and open source software developers’ code-writing efforts are allocated within open source projects.
Jean-Michel Dalle, Paul A. David
core
Automatic generation of raw interface code, in web environments from a database for free software environments [PDF]
, 2013 La investigación de este proyecto, radica en proponer a la comunidad de software libre una herramienta que permita generar de forma automática aplicaciones con interfaces CRUD, a partir de una base de datos, con el motor mySQL.
Mendoza Moreno, Juan Francisco
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Structure-based drug design of an inhibitor of the SARS-CoV-2 (COVID-19) main protease using free software: A tutorial for students and scientists. [PDF]
Eur J Med Chem, 2021 Zhang S +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Contracting with free software communities
Industry and large Agencies needs ¿agile¿ programming resources, to reinforce their own development staff and take advantage of innovative approaches produced by ¿fresh minds¿ all over the world.
Schmitz, Patrice-Emmanuel
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 2017 Today has significant empirical use of free software in educational activities. The researchers studied various aspects of use, which include forms and methods of educational activity, advantages and disadvantages of free software eligibility criteria of
Величко, Владислав Євгенович
core
A newly developed free software tool set for averaging electroencephalogram implemented in the Perl programming language. [PDF]
Heliyon, 2020 Suwazono S, Arao H.
europepmc +1 more source