Results 111 to 120 of about 4,892,815 (298)

Technological Sovereignty: What Chances for Alternative Practices to Emerge in Daily IT Use?

open access: yesHybrid, 2016
This paper presents the tension between commercial monopolistic practices offered by Google, Amazon, Facebook, Apple and Microsoft (GAFAM) in terms of IT and the possible conditions of alternative practices.
Natalia Calderón Beltrán
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Lifecycle management in government-driven open source projects – practical framework

open access: yesInternational Journal of Information Systems and Project Management, 2022
In many parts of the world, public sector organizations are increasingly interested in collaborating across organizational (and even national) boundaries to develop software solutions under an open licence.
Katja Henttonen   +2 more
doaj  

On the role of public policies supporting Free/Open Source Software: an European perspective [PDF]

open access: yes, 2006
Available in the ...
Comino, Stefano   +2 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

"Free Software, Free Society"?

open access: yes, 2013
Freie Software wird von Communities entwickelt und verbreitet. Die hier aktiven Personen wollen sich und andere in die Lage versetzen, technische Artefakte selbst mitzugestalten, statt sie als gegeben hinzunehmen. Sie streben zudem einen besonders offenen Umgang mit Wissen an.
openaire   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Social justice and an information democracy with free and open source software [PDF]

open access: yes, 2011
This paper includes some thoughts on the implications of proprietary software versus free and open source software with regards to social justice, capital, and notions of an information society versus an information democracy.
Burns, Sean C.
core  

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