Results 51 to 60 of about 13,293,810 (294)
Influence of HPT Deformation on the Structure and Properties of Amorphous Alloys
Recent studies showed that structural changes in amorphous alloys under high pressure torsion (HPT) are determined by their chemical composition and processing regimes.
Dmitry Gunderov, Vasily Astanin
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
A series of novel solvent-free oligomeric electrolytes based on poly (ethyl glycol) methyl ether methacrylate for dye-sensitized solar cells (DSSCs) are currently under development. The aim of this study was to investigate the effects of tri-iodine (I3-)
Fu-Ming Wang +8 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structural Stability and Glass-Forming Ability of Fe74B20Nb2Hf2Si2: The Role of Cooling Rate [PDF]
This study investigates the effect of cooling rate on the glass transition behavior of the Fe74B20Nb2Hf2Si2 soft magnetic amorphous alloy. Rectangular samples with two different dimensions, 70.0 mm × 1.0 mm × 1.0 mm, and 50.0 mm × 30.0 mm × 0.5 mm, were ...
P. Rezaei-Shahreza +3 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The one-body free volume, which determines the entropy of a hard disk system, has extensive (cavity) and intensive (cell) contributions. So far these contributions have not been unified and considered separately.
V. M. Pergamenshchik
doaj +1 more source
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source

